Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

Oxidative stress determines cell fate through several mechanisms, among which regulation of mRNA translation by the phosphorylation of the alpha (α) subunit of the translation initiation factor eIF2α at serine 51 (eIF2αP) plays a prominent role. Increased eIF2αP can contribute to tumor progression a...

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Detalles Bibliográficos
Autores principales: Krishnamoorthy, Jothilatha, Tenkerian, Clara, Gupta, Jyotsana, Ghaddar, Nour, Wang, Shuo, Darini, Cedric, Staschke, Kirk A., Ghosh, Abhishek, Gandin, Valentina, Topisirovic, Ivan, Kristof, Arnold S., Hatzoglou, Maria, Simos, George, Koromilas, Antonis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833713/
https://www.ncbi.nlm.nih.gov/pubmed/29449538
http://dx.doi.org/10.1038/s41419-018-0326-2

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