Arsenic trioxide promoting ETosis in acute promyelocytic leukemia through mTOR-regulated autophagy

Despite the high efficacy and safety of arsenic trioxide (ATO) in treating acute promyelocytic leukemia (APL) and eradicating APL leukemia-initiating cells (LICs), the mechanism underlying its selective cytotoxicity remains elusive. We have recently demonstrated that APL cells undergo a novel cell d...

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Detalles Bibliográficos
Autores principales: Li, Tao, Ma, Ruishuang, Zhang, Yan, Mo, Hongdan, Yang, Xiaoyan, Hu, Shaoshan, Wang, Lixiu, Novakovic, Valerie A, Chen, He, Kou, Junjie, Bi, Yayan, Yu, Bo, Fang, Shaohong, Wang, Jinghua, Zhou, Jin, Shi, Jialan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833714/
https://www.ncbi.nlm.nih.gov/pubmed/29362482
http://dx.doi.org/10.1038/s41419-017-0018-3

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