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Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy
The receptor for advanced glycation end products (Rage) is involved in the development of various tumors and acts as an oncogenic protein. Rage is overexpressed in tumors including hepatocellular carcinoma (HCC). However, the molecular mechanism of Rage in HCC progression and sorafenib resistance re...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833717/ https://www.ncbi.nlm.nih.gov/pubmed/29445087 http://dx.doi.org/10.1038/s41419-018-0329-z |
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author | Li, Jun Wu, Peng-Wen Zhou, Yuan Dai, Bo Zhang, Peng-Fei Zhang, Yu-Hen Liu, Yang Shi, Xiao-Lei |
author_facet | Li, Jun Wu, Peng-Wen Zhou, Yuan Dai, Bo Zhang, Peng-Fei Zhang, Yu-Hen Liu, Yang Shi, Xiao-Lei |
author_sort | Li, Jun |
collection | PubMed |
description | The receptor for advanced glycation end products (Rage) is involved in the development of various tumors and acts as an oncogenic protein. Rage is overexpressed in tumors including hepatocellular carcinoma (HCC). However, the molecular mechanism of Rage in HCC progression and sorafenib resistance remains unclear. In this study, enhanced Rage expression is highly associated proliferation and contributes to sorafenib resistance. Rage deficiency contributed to autophagy induction through activating AMPK/mTOR signaling pathway, which is important for sorafenib response. Moreover, the interactions between Rage and Rage ligands such as high mobility group box 1 (HMGB1) and s100a4 positively increased Rage expression. Our data indicate that Rage may be a potential target for therapeutic intervention in HCC and biomarker for sorafenib resistance. |
format | Online Article Text |
id | pubmed-5833717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58337172018-03-06 Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy Li, Jun Wu, Peng-Wen Zhou, Yuan Dai, Bo Zhang, Peng-Fei Zhang, Yu-Hen Liu, Yang Shi, Xiao-Lei Cell Death Dis Article The receptor for advanced glycation end products (Rage) is involved in the development of various tumors and acts as an oncogenic protein. Rage is overexpressed in tumors including hepatocellular carcinoma (HCC). However, the molecular mechanism of Rage in HCC progression and sorafenib resistance remains unclear. In this study, enhanced Rage expression is highly associated proliferation and contributes to sorafenib resistance. Rage deficiency contributed to autophagy induction through activating AMPK/mTOR signaling pathway, which is important for sorafenib response. Moreover, the interactions between Rage and Rage ligands such as high mobility group box 1 (HMGB1) and s100a4 positively increased Rage expression. Our data indicate that Rage may be a potential target for therapeutic intervention in HCC and biomarker for sorafenib resistance. Nature Publishing Group UK 2018-02-14 /pmc/articles/PMC5833717/ /pubmed/29445087 http://dx.doi.org/10.1038/s41419-018-0329-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Li, Jun Wu, Peng-Wen Zhou, Yuan Dai, Bo Zhang, Peng-Fei Zhang, Yu-Hen Liu, Yang Shi, Xiao-Lei Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy |
title | Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy |
title_full | Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy |
title_fullStr | Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy |
title_full_unstemmed | Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy |
title_short | Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy |
title_sort | rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833717/ https://www.ncbi.nlm.nih.gov/pubmed/29445087 http://dx.doi.org/10.1038/s41419-018-0329-z |
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