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Molecular and physiological roles of the adaptor protein CARD9 in immunity
CARD9 is a caspase recruitment domain-containing signaling protein that plays a critical role in innate and adaptive immunity. It has been widely demonstrated that CARD9 adaptor allows pattern recognition receptors to induce NF-κB and MAPK activation, which initiates a “downstream” inflammation cyto...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833731/ https://www.ncbi.nlm.nih.gov/pubmed/29352133 http://dx.doi.org/10.1038/s41419-017-0084-6 |
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author | Zhong, Xiaoming Chen, Bin Yang, Liang Yang, Zhiwen |
author_facet | Zhong, Xiaoming Chen, Bin Yang, Liang Yang, Zhiwen |
author_sort | Zhong, Xiaoming |
collection | PubMed |
description | CARD9 is a caspase recruitment domain-containing signaling protein that plays a critical role in innate and adaptive immunity. It has been widely demonstrated that CARD9 adaptor allows pattern recognition receptors to induce NF-κB and MAPK activation, which initiates a “downstream” inflammation cytokine cascade and provides effective protection against microbial invasion, especially fungal infection. Here our aim is to update existing paradigms and summarize the most recent findings on the CARD9 signaling pathway, revealing significant mechanistic insights into the pathogenesis of CARD9 deficiency. We also discuss the effect of CARD9 genetic mutations on the in vivo immune response, and highlight clinical advances in non-infection inflammation. |
format | Online Article Text |
id | pubmed-5833731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58337312018-03-06 Molecular and physiological roles of the adaptor protein CARD9 in immunity Zhong, Xiaoming Chen, Bin Yang, Liang Yang, Zhiwen Cell Death Dis Review Article CARD9 is a caspase recruitment domain-containing signaling protein that plays a critical role in innate and adaptive immunity. It has been widely demonstrated that CARD9 adaptor allows pattern recognition receptors to induce NF-κB and MAPK activation, which initiates a “downstream” inflammation cytokine cascade and provides effective protection against microbial invasion, especially fungal infection. Here our aim is to update existing paradigms and summarize the most recent findings on the CARD9 signaling pathway, revealing significant mechanistic insights into the pathogenesis of CARD9 deficiency. We also discuss the effect of CARD9 genetic mutations on the in vivo immune response, and highlight clinical advances in non-infection inflammation. Nature Publishing Group UK 2018-01-19 /pmc/articles/PMC5833731/ /pubmed/29352133 http://dx.doi.org/10.1038/s41419-017-0084-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Zhong, Xiaoming Chen, Bin Yang, Liang Yang, Zhiwen Molecular and physiological roles of the adaptor protein CARD9 in immunity |
title | Molecular and physiological roles of the adaptor protein CARD9 in immunity |
title_full | Molecular and physiological roles of the adaptor protein CARD9 in immunity |
title_fullStr | Molecular and physiological roles of the adaptor protein CARD9 in immunity |
title_full_unstemmed | Molecular and physiological roles of the adaptor protein CARD9 in immunity |
title_short | Molecular and physiological roles of the adaptor protein CARD9 in immunity |
title_sort | molecular and physiological roles of the adaptor protein card9 in immunity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833731/ https://www.ncbi.nlm.nih.gov/pubmed/29352133 http://dx.doi.org/10.1038/s41419-017-0084-6 |
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