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Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

Treatment of intervertebral disc degeneration (IDD) seeks to prevent senescence and death of nucleus pulposus (NP) cells. Previous studies have shown that sirt6 exerts potent anti-senescent and anti-apoptotic effects in models of age-related degenerative disease. However, it is not known whether sir...

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Detalles Bibliográficos
Autores principales:	Chen, Jian, Xie, Jun-Jun, Jin, Meng-Yun, Gu, Yun-Tao, Wu, Cong-Cong, Guo, Wei-Jun, Yan, Ying-Zhao, Zhang, Zeng-Jie, Wang, Jian-Le, Zhang, Xiao-Lei, Lin, Yan, Sun, Jia-Li, Zhu, Guang-Hui, Wang, Xiang-Yang, Wu, Yao-Sen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833741/ https://www.ncbi.nlm.nih.gov/pubmed/29352194 http://dx.doi.org/10.1038/s41419-017-0085-5

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