Cargando…

Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway

BACKGROUND: Multidrug resistance (MDR) frequently contributes to the failure of chemotherapeutic treatments in patients diagnosed with hepatocellular carcinoma (HCC). Revealing the molecular mechanism of MDR is indispensable for the development of effective chemotherapeutic drugs. PURPOSE: Due to th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Chendong, Hou, Aihua, Yu, Chunfeng, Dai, Lingling, Wang, Wen, Zhang, Kangle, Shao, Hongmin, Ma, Jinghua, Xu, Wenjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833758/ https://www.ncbi.nlm.nih.gov/pubmed/29520149 http://dx.doi.org/10.2147/OTT.S153814

Ejemplares similares

Aidi Injection, Compound Kushen Injection, or Kanglaite Injection: Which Is the Best Partner with Systemic Chemotherapy for Patients with HCC? A Network Meta-Analysis
por: Dou, Dou, et al.
Publicado: (2020)

USP35 promotes HCC development by stabilizing ABHD17C and activating the PI3K/AKT signaling pathway
por: Wang, Linpei, et al.
Publicado: (2023)

Antitumor effect of Kanglaite® injection in human pancreatic cancer xenografts
por: Liu, Ying, et al.
Publicado: (2014)

Efficacy of Paclitaxel Combined with Kanglaite Injection in Treatment of Bone Metastases of Lung Cancer
por: CAO, Liming, et al.
Publicado: (2019)

Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer
por: Wu, Yue, et al.
Publicado: (2018)

Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes
por: SHAN, SHI-JUN, et al.
Publicado: (2011)

Efficacy and safety of Kanglaite injection for gastric cancer: A protocol for systematic review and meta-analysis
por: Hou, Daorui, et al.
Publicado: (2020)

ARHGAP20 Expression Inhibited HCC Progression by Regulating the PI3K-AKT Signaling Pathway
por: Liu, Gao, et al.
Publicado: (2021)

Chidamide Combined With Doxorubicin Induced p53-Driven Cell Cycle Arrest and Cell Apoptosis Reverse Multidrug Resistance of Breast Cancer
por: Cao, Lixia, et al.
Publicado: (2021)

Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway
por: Wu, Tianchun, et al.
Publicado: (2018)

Kanglaite inhibits EMT caused by TNF-α via NF-κΒ inhibition in colorectal cancer cells
por: Shi, Guiling, et al.
Publicado: (2017)

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
por: Wang, Yijia, et al.
Publicado: (2017)

Efficacy and safety of Kanglaite injection combined with chemotherapy for colorectal cancer: A protocol for systematic review and meta-analysis
por: Mao, Weili, et al.
Publicado: (2020)

Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer
por: Zhao, Mei, et al.
Publicado: (2023)

Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis of NSCLC Cells through the PI3K/Akt/GSK-3β Pathway
por: Kim, Sang-A, et al.
Publicado: (2018)

Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis
por: Yuan, Fuwen, et al.
Publicado: (2018)

4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells
por: Gao, Xiang, et al.
Publicado: (2021)

Chinese herb related molecules of cancer-cell-apoptosis: a minireview of progress between Kanglaite injection and related genes
por: Lu, Yun, et al.
Publicado: (2008)

Efficacy and safety of Kanglaite injection combined with radiochemotherapy in the treatment of advanced pancreatic cancer: A PRISMA-compliant meta-analysis
por: Liu, Jianling, et al.
Publicado: (2019)

Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity
por: Cao, Ning, et al.
Publicado: (2016)

The clinical efficacy and safety of kanglaite adjuvant therapy in the treatment of advanced hepatocellular carcinoma: A PRISMA-compliant meta-analysis
por: Liu, Jingjing, et al.
Publicado: (2019)

Kanglaite (Coix Seed Extract) as Adjunctive Therapy in Cancer: Evidence Mapping Overview Based on Systematic Reviews With Meta-Analyses
por: Lu, Cuncun, et al.
Publicado: (2022)

iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment
por: Andrade, Adriana, et al.
Publicado: (2022)

The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K/Akt/NF-κB signal pathway in nasopharynx carcinoma
por: Liu, Jin, et al.
Publicado: (2020)

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
por: Liu, Rui, et al.
Publicado: (2020)

Pectolinarigenin Induced Cell Cycle Arrest, Autophagy, and Apoptosis in Gastric Cancer Cell via PI3K/AKT/mTOR Signaling Pathway
por: Lee, Ho Jeong, et al.
Publicado: (2018)

TOFA induces cell cycle arrest and apoptosis in ACHN and 786-O cells through inhibiting PI3K/Akt/mTOR pathway
por: He, Dejiao, et al.
Publicado: (2018)

The Effects of Autophagy and PI3K/AKT/m-TOR Signaling Pathway on the Cell-Cycle Arrest of Rats Primary Sertoli Cells Induced by Zearalenone
por: Wang, Bing-jie, et al.
Publicado: (2018)

Raddeanin A Induces Apoptosis and Cycle Arrest in Human HCT116 Cells through PI3K/AKT Pathway Regulation In Vitro and In Vivo
por: Meng, Chunqin, et al.
Publicado: (2019)

MST4 inhibits human hepatocellular carcinoma cell proliferation and induces cell cycle arrest via suppression of PI3K/AKT pathway
por: Hao, Wei-Chao, et al.
Publicado: (2020)

Author Correction: Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
por: Wang, Yijia, et al.
Publicado: (2018)

Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells
por: Chengye, Wang, et al.
Publicado: (2017)

MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis
por: Dian, Mei-Juan, et al.
Publicado: (2021)

LRP1B suppresses HCC progression through the NCSTN/PI3K/AKT signaling axis and affects doxorubicin resistance
por: Zhai, Xiangyu, et al.
Publicado: (2022)

Cell Cycle Arrest and Cell Survival Induce Reverse Trends of Cardiolipin Remodeling
por: Chao, Yu-Jen, et al.
Publicado: (2014)

Cell cycle exits and U-turns: Quiescence as multiple reversible forms of arrest
por: Johnson, Martha Sharisha, et al.
Publicado: (2023)

Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1
por: Ma, Hongye, et al.
Publicado: (2014)

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
por: Roy, Sanjit K, et al.
Publicado: (2010)

Antitumor Activity of Tenacissoside H on Esophageal Cancer through Arresting Cell Cycle and Regulating PI3K/Akt-NF-κB Transduction Cascade
por: Jia, Yong-sen, et al.
Publicado: (2015)

Plumbagin induces RPE cell cycle arrest and apoptosis via p38 MARK and PI3K/AKT/mTOR signaling pathways in PVR
por: Chen, Haiting, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2gf7199tp9afdn117v3jorm1it