Lup-20(29)-en-3β,28-di-yl-nitrooxy acetate affects MCF-7 proliferation through the crosstalk between apoptosis and autophagy in mitochondria

Betulin (BT), a pentacyclic lupine-type triterpenoid natural product, possesses antitumor activity in various types of cancers. However, its clinical development was discouraged due to its low biological activities and poor solubility. We prepared lup-20(29)-en-3β,28-di-yl-nitrooxy acetate (NBT), a...

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Detalles Bibliográficos
Autores principales: Yan, Xiaoning, Yang, Lei, Feng, Gaili, Yu, Zhuli, Xiao, Minjie, Cai, Weibin, Xing, Yanmei, Bai, Shasha, Guo, Junqia, Wang, Zhiyu, Wang, Tao, Zhang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833777/
https://www.ncbi.nlm.nih.gov/pubmed/29445224
http://dx.doi.org/10.1038/s41419-017-0255-5

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