Cargando…

Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip

Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely on use of animal models because culture systems do not faithfully mimic human intestinal physiology. Here we used a human Gut-on-a-Chip (Gut Chip) microfluidic device lined by human intestinal epithelial cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jalili-Firoozinezhad, Sasan, Prantil-Baun, Rachelle, Jiang, Amanda, Potla, Ratnakar, Mammoto, Tadanori, Weaver, James C., Ferrante, Thomas C., Kim, Hyun Jung, Cabral, Joaquim M. S., Levy, Oren, Ingber, Donald E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833800/ https://www.ncbi.nlm.nih.gov/pubmed/29445080 http://dx.doi.org/10.1038/s41419-018-0304-8

Ejemplares similares

Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology
por: Sontheimer-Phelps, Alexandra, et al.
Publicado: (2019)

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
por: Jalili-Firoozinezhad, Sasan, et al.
Publicado: (2019)

AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage
por: Li, Juan, et al.
Publicado: (2019)

Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip
por: Si, Longlong, et al.
Publicado: (2021)

Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction
por: Bein, Amir, et al.
Publicado: (2022)

Microfluidic Organ-on-a-Chip Models of Human Intestine
por: Bein, Amir, et al.
Publicado: (2018)

On-chip recapitulation of clinical bone-marrow toxicities and patient-specific pathophysiology
por: Chou, David B., et al.
Publicado: (2020)

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites
por: Tovaglieri, Alessio, et al.
Publicado: (2019)

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip
por: Musah, Samira, et al.
Publicado: (2017)

Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip
por: Goyal, Girija, et al.
Publicado: (2022)

Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip (Adv. Sci. 14/2022)
por: Goyal, Girija, et al.
Publicado: (2022)

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids
por: Kasendra, Magdalena, et al.
Publicado: (2018)

Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip
por: Bai, Haiqing, et al.
Publicado: (2022)

Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro
por: Villenave, Remi, et al.
Publicado: (2017)

LRP5 Regulates Development of Lung Microvessels and Alveoli through the Angiopoietin-Tie2 Pathway
por: Mammoto, Tadanori, et al.
Publicado: (2012)

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip
por: Mahajan, Gautam, et al.
Publicado: (2022)

Fabrication and Characterization of Spongy Denuded Amniotic Membrane Based Scaffold for Tissue Engineering
por: Taghiabadi, Ehsan, et al.
Publicado: (2015)

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
por: Park, Tae-Eun, et al.
Publicado: (2019)

Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration
por: Mammoto, Akiko, et al.
Publicado: (2019)

LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung
por: Mammoto, Akiko, et al.
Publicado: (2019)

Extracellular Matrix in Aging Aorta
por: Mammoto, Akiko, et al.
Publicado: (2022)

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
por: Bein, Amir, et al.
Publicado: (2021)

Editorial: Organ microenvironment in vascular formation, homeostasis and engineering
por: Mammoto, Akiko, et al.
Publicado: (2023)

Endothelial Twist1-PDGFB signaling mediates hypoxia-induced proliferation and migration of αSMA-positive cells
por: Mammoto, Akiko, et al.
Publicado: (2020)

Comprehensive evaluation of poly(I:C) induced inflammatory response in an airway epithelial model
por: Lever, Amanda R, et al.
Publicado: (2015)

Twist1 signaling in age-dependent decline in angiogenesis and lung regeneration
por: Hendee, Kathryn, et al.
Publicado: (2021)

Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling
por: Hunyenyiwa, Tendai, et al.
Publicado: (2021)

Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
por: Kyi, Priscilla, et al.
Publicado: (2022)

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics
por: Ingber, Donald E.
Publicado: (2023)

Human organs-on-chips for disease modelling, drug development and personalized medicine
por: Ingber, Donald E.
Publicado: (2022)

Shifts in temperature within the physiologic range modify strand-specific expression of select human microRNAs
por: Potla, Ratnakar, et al.
Publicado: (2015)

Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip
por: Shin, Woojung, et al.
Publicado: (2019)

Network radar countermeasure systems: integrating radar and radar countermeasures
por: Jiang, Qiuxi
Publicado: (2016)

Twist1 Controls Lung Vascular Permeability and Endotoxin-Induced Pulmonary Edema by Altering Tie2 Expression
por: Mammoto, Tadanori, et al.
Publicado: (2013)

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1
por: Mammoto, Tadanori, et al.
Publicado: (2019)

Quantifying cell-generated mechanical forces within living embryonic tissues
por: Campàs, Otger, et al.
Publicado: (2013)

ECMO as an emergency medical countermeasure
por: Paul, Subroto, et al.
Publicado: (2014)

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
por: Si, Longlong, et al.
Publicado: (2021)

Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?
por: Ingber, Donald E.
Publicado: (2020)

Temporal dynamics of intradermal cytokine response to tuberculin in Mycobacterium bovis BCG-vaccinated cattle using sampling microneedles
por: Steinbach, Sabine, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1dpj56g09j8rlouqpbr4chb1p3