Let-7 microRNA controls invasion-promoting lysosomal changes via the oncogenic transcription factor myeloid zinc finger-1

Cancer cells utilize lysosomes for invasion and metastasis. Myeloid Zinc Finger1 (MZF1) is an ErbB2-responsive transcription factor that promotes invasion of breast cancer cells via upregulation of lysosomal cathepsins B and L. Here we identify let-7 microRNA, a well-known tumor suppressor in breast...

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Detalles Bibliográficos
Autores principales: Tvingsholm, Siri Amanda, Hansen, Malene Bredahl, Clemmensen, Knut Kristoffer Bundgaard, Brix, Ditte Marie, Rafn, Bo, Frankel, Lisa B, Louhimo, Riku, Moreira, José, Hautaniemi, Sampsa, Gromova, Irina, Jäättelä, Marja, Kallunki, Tuula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833801/
https://www.ncbi.nlm.nih.gov/pubmed/29396433
http://dx.doi.org/10.1038/s41389-017-0014-6

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