Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis

Type-II L-arginine:ureahydrolase, arginase-II (Arg-II), is shown to activate mechanistic target of rapamycin complex 1 (mTORC1) pathway and contributes to cell senescence and apoptosis. In an attempt to elucidate the underlying mechanism, we identified myosin-1b (Myo1b) as a mediator. Overexpression...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Yi, Xiong, Yuyan, Montani, Jean-Pierre, Yang, Zhihong, Ming, Xiu-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833809/
https://www.ncbi.nlm.nih.gov/pubmed/29472548
http://dx.doi.org/10.1038/s41419-018-0356-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833809/
https://www.ncbi.nlm.nih.gov/pubmed/29472548
http://dx.doi.org/10.1038/s41419-018-0356-9

Ejemplares similares