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Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy

Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, w...

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Detalles Bibliográficos
Autores principales:	Bessa, Cláudia, Soares, Joana, Raimundo, Liliana, Loureiro, Joana B., Gomes, Célia, Reis, Flávio, Soares, Miguel L., Santos, Daniel, Dureja, Chetna, Chaudhuri, Saumya R., Lopez-Haber, Cynthia, Kazanietz, Marcelo G., Gonçalves, Jorge, Simões, Maria F., Rijo, Patrícia, Saraiva, Lucília
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833815/ https://www.ncbi.nlm.nih.gov/pubmed/29348560 http://dx.doi.org/10.1038/s41419-017-0154-9

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