Cargando…

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy

Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bessa, Cláudia, Soares, Joana, Raimundo, Liliana, Loureiro, Joana B., Gomes, Célia, Reis, Flávio, Soares, Miguel L., Santos, Daniel, Dureja, Chetna, Chaudhuri, Saumya R., Lopez-Haber, Cynthia, Kazanietz, Marcelo G., Gonçalves, Jorge, Simões, Maria F., Rijo, Patrícia, Saraiva, Lucília
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833815/ https://www.ncbi.nlm.nih.gov/pubmed/29348560 http://dx.doi.org/10.1038/s41419-017-0154-9

Ejemplares similares

DIMP53‐1: a novel small‐molecule dual inhibitor of p53–MDM2/X interactions with multifunctional p53‐dependent anticancer properties
por: Soares, Joana, et al.
Publicado: (2017)

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma
por: Gomes, Sara, et al.
Publicado: (2019)

Contribution of Yeast Models to Neurodegeneration Research
por: Pereira, Clara, et al.
Publicado: (2012)

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule
por: Soares, Joana, et al.
Publicado: (2015)

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator
por: Bessa, Cláudia, et al.
Publicado: (2023)

Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness
por: Moreira, Joana, et al.
Publicado: (2021)

Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities
por: Matias, Diogo, et al.
Publicado: (2019)

Phylogenetic Distribution and Prevalence of Genes Encoding Class I Integrons and CTX-M-15 Extended-Spectrum β-Lactamases in Escherichia coli Isolates from Healthy Humans in Chandigarh, India
por: Dureja, Chetna, et al.
Publicado: (2014)

Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target
por: Raimundo, Liliana, et al.
Publicado: (2021)

Draft Genome Sequence of the Opportunistic Human Pathogen Morganella morganii SC01
por: Khatri, Indu, et al.
Publicado: (2013)

Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance
por: Loureiro, Joana B., et al.
Publicado: (2021)

Structure–Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization
por: Moreira, Joana, et al.
Publicado: (2023)

Evidence of a new metabolic capacity in an emerging diarrheal pathogen: lessons from the draft genomes of Vibrio fluvialis strains PG41 and I21563
por: Khatri, Indu, et al.
Publicado: (2013)

Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells
por: Sancha, Shirley A. R., et al.
Publicado: (2022)

Xylose fermentation efficiency of industrial Saccharomyces cerevisiae yeast with separate or combined xylose reductase/xylitol dehydrogenase and xylose isomerase pathways
por: Cunha, Joana T., et al.
Publicado: (2019)

Bioactive Diarylpentanoids: Insights into the Biological Effects beyond Antitumor Activity and Structure–Activity Relationships
por: Moreira, Joana, et al.
Publicado: (2022)

Cytotoxic Activity of Royleanone Diterpenes from Plectranthus madagascariensis Benth
por: Matias, Diogo, et al.
Publicado: (2019)

Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity
por: Andrade, Joana M, et al.
Publicado: (2018)

Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53
por: Long, Solida, et al.
Publicado: (2021)

Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
por: Cunha, Joana T., et al.
Publicado: (2020)

The environmental performance of tall buildings /
por: Gonçalves, Joana Carla Soares
Publicado: (2010)

3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1H-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents
por: Ribeiro, João L. P., et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents
por: Lemos, Agostinho, et al.
Publicado: (2019)

Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators
por: Barcherini, Valentina, et al.
Publicado: (2023)

Antisense Transcription across Nucleotide Repeat Expansions in Neurodegenerative and Neuromuscular Diseases: Progress and Mysteries
por: Castro, Ana F., et al.
Publicado: (2020)

Deciphering the Role of p53 and TAp73 in Neuroblastoma: From Pathogenesis to Treatment
por: Almeida, Joana, et al.
Publicado: (2022)

Parvifloron D from Plectranthus strigosus: Cytotoxicity Screening of Plectranthus spp. Extracts
por: Garcia, Catarina, et al.
Publicado: (2019)

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy
por: Dureja, Chetna, et al.
Publicado: (2023)

Non-Small Cell Lung Carcinoma Cell Motility, Rac Activation and Metastatic Dissemination Are Mediated by Protein Kinase C Epsilon
por: Caino, M. Cecilia, et al.
Publicado: (2012)

How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer
por: Prazeres, Hugo, et al.
Publicado: (2011)

Corrigendum to “How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer”
por: Prazeres, Hugo, et al.
Publicado: (2016)

Establishment of Kluyveromyces marxianus as a Microbial Cell Factory for Lignocellulosic Processes: Production of High Value Furan Derivatives
por: Baptista, Marlene, et al.
Publicado: (2021)

The Association of Metabolic Dysfunction and Mood Across Lifespan Interacts With the Default Mode Network Functional Connectivity
por: Portugal-Nunes, Carlos, et al.
Publicado: (2021)

Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure—Activity Relationship Studies
por: Moreira, Joana, et al.
Publicado: (2023)

GFAPδ: A Promising Biomarker and Therapeutic Target in Glioblastoma
por: Radu, Roxana, et al.
Publicado: (2022)

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications
por: Rebelo, Catarina, et al.
Publicado: (2022)

Author Correction: Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications
por: Rebelo, Catarina, et al.
Publicado: (2023)

Oral Yeast Colonization and Fungal Infections in Peritoneal Dialysis Patients: A Pilot Study
por: Simões-Silva, Liliana, et al.
Publicado: (2017)

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations
por: Preto, Ana, et al.
Publicado: (2009)

Enhanced Anticancer Activity of Hymenocardia acida Stem Bark Extract Loaded into PLGA Nanoparticles
por: Adedokun, Oluwasegun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_onkpun67ii1gj6mg2818vns8sd