Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity

Deltarasin is a recently identified small molecule that can inhibit KRAS–PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF signaling in human pancreatic ductal adenocarcinoma cell lines. Since KRAS mutations are the m...

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Detalles Bibliográficos
Autores principales: Leung, Elaine Lai Han, Luo, Lian Xiang, Liu, Zhong Qiu, Wong, Vincent Kam Wai, Lu, Lin Lin, Xie, Ying, Zhang, Ni, Qu, Yuan Qing, Fan, Xing Xing, Li, Ying, Huang, Min, Xiao, Dai Kai, Huang, Jun, Zhou, Yan Ling, He, Jian Xing, Ding, Jian, Yao, Xiao Jun, Ward, David C., Liu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833846/
https://www.ncbi.nlm.nih.gov/pubmed/29440631
http://dx.doi.org/10.1038/s41419-017-0065-9

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