EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8(+) T cells primarily t...

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Detalles Bibliográficos
Autores principales: Squadrito, Mario Leonardo, Cianciaruso, Chiara, Hansen, Sarah K., De Palma, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833950/
https://www.ncbi.nlm.nih.gov/pubmed/29355847
http://dx.doi.org/10.1038/nmeth.4579
Descripción
Sumario:We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8(+) T cells primarily through MHCI recycling and cross-dressing. EVIR-engineered DCs may increase the applications of DC-based cancer vaccines.

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