EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8(+) T cells primarily t...

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Detalles Bibliográficos
Autores principales: Squadrito, Mario Leonardo, Cianciaruso, Chiara, Hansen, Sarah K., De Palma, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833950/
https://www.ncbi.nlm.nih.gov/pubmed/29355847
http://dx.doi.org/10.1038/nmeth.4579
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author Squadrito, Mario Leonardo
Cianciaruso, Chiara
Hansen, Sarah K.
De Palma, Michele
author_facet Squadrito, Mario Leonardo
Cianciaruso, Chiara
Hansen, Sarah K.
De Palma, Michele
author_sort Squadrito, Mario Leonardo
collection PubMed
description We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8(+) T cells primarily through MHCI recycling and cross-dressing. EVIR-engineered DCs may increase the applications of DC-based cancer vaccines.
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spelling pubmed-58339502018-07-22 EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens Squadrito, Mario Leonardo Cianciaruso, Chiara Hansen, Sarah K. De Palma, Michele Nat Methods Article We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8(+) T cells primarily through MHCI recycling and cross-dressing. EVIR-engineered DCs may increase the applications of DC-based cancer vaccines. 2018-01-22 2018-03 /pmc/articles/PMC5833950/ /pubmed/29355847 http://dx.doi.org/10.1038/nmeth.4579 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Squadrito, Mario Leonardo
Cianciaruso, Chiara
Hansen, Sarah K.
De Palma, Michele
EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
title EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
title_full EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
title_fullStr EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
title_full_unstemmed EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
title_short EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
title_sort evir: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833950/
https://www.ncbi.nlm.nih.gov/pubmed/29355847
http://dx.doi.org/10.1038/nmeth.4579
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AT depalmamichele evirchimericreceptorsthatenhancedendriticcellcrossdressingwithtumorantigens

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