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EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8(+) T cells primarily t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833950/ https://www.ncbi.nlm.nih.gov/pubmed/29355847 http://dx.doi.org/10.1038/nmeth.4579 |