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Autoregulation of von Willebrand factor function by a disulfide bond switch

Force-dependent binding of platelet glycoprotein Ib (GPIb) receptors to plasma von Willebrand factor (VWF) plays a key role in hemostasis and thrombosis. Previous studies have suggested that VWF activation requires force-induced exposure of the GPIb binding site in the A1 domain that is autoinhibite...

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Detalles Bibliográficos
Autores principales:	Butera, Diego, Passam, Freda, Ju, Lining, Cook, Kristina M., Woon, Heng, Aponte-Santamaría, Camilo, Gardiner, Elizabeth, Davis, Amanda K., Murphy, Deirdre A., Bronowska, Agnieszka, Luken, Brenda M., Baldauf, Carsten, Jackson, Shaun, Andrews, Robert, Gräter, Frauke, Hogg, Philip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834005/ https://www.ncbi.nlm.nih.gov/pubmed/29507883 http://dx.doi.org/10.1126/sciadv.aaq1477

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