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Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer

BACKGROUND: Mutations in rat sarcoma (RAS) genes may be a mechanism of secondary resistance in epidermal growth factor receptor inhibitor-treated patients. Tumor-tissue biopsy testing has been the standard for evaluating mutational status; however, plasma testing of cell-free DNA has been shown to b...

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Detalles Bibliográficos
Autores principales:	Siena, S, Sartore-Bianchi, A, Garcia-Carbonero, R, Karthaus, M, Smith, D, Tabernero, J, Van Cutsem, E, Guan, X, Boedigheimer, M, Ang, A, Twomey, B, Bach, B A, Jung, A S, Bardelli, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834114/ https://www.ncbi.nlm.nih.gov/pubmed/28945848 http://dx.doi.org/10.1093/annonc/mdx504

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