Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring

Proliferating cell nuclear antigen (PCNA), a homotrimeric protein, is the eukaryotic sliding clamp that functions as a processivity factor for polymerases during DNA replication. Chromatin association factor 1 (CAF-1) is a heterotrimeric histone chaperone protein that is required for coupling chroma...

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Detalles Bibliográficos
Autores principales: Kondratick, Christine M., Litman, Jacob M., Shaffer, Kurt V., Washington, M. Todd, Dieckman, Lynne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834165/
https://www.ncbi.nlm.nih.gov/pubmed/29499038
http://dx.doi.org/10.1371/journal.pone.0193333

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