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Structural basis of ribosomal peptide macrocyclization in plants

Constrained, cyclic peptides encoded by plant genes represent a new generation of drug leads. Evolution has repeatedly recruited the Cys-protease asparaginyl endopeptidase (AEP) to perform their head-to-tail ligation. These macrocyclization reactions use the substrates amino terminus instead of wate...

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Detalles Bibliográficos
Autores principales:	Haywood, Joel, Schmidberger, Jason W, James, Amy M, Nonis, Samuel G, Sukhoverkov, Kirill V, Elias, Mikael, Bond, Charles S, Mylne, Joshua S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834244/ https://www.ncbi.nlm.nih.gov/pubmed/29384475 http://dx.doi.org/10.7554/eLife.32955

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