Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells

Fusion proteins combining hexavalent TRAIL with antibody fragments allow for a targeted delivery and efficient apoptosis induction in tumor cells. Here, we analyzed scFv-Fc-scTRAIL molecules directed against EGFR, HER2, HER3, and EpCAM as well as an untargeted Fc-scTRAIL fusion protein for their pot...

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Detalles Bibliográficos
Autores principales: Hutt, Meike, Fellermeier-Kopf, Sina, Seifert, Oliver, Schmitt, Lisa C., Pfizenmaier, Klaus, Kontermann, Roland E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834252/
https://www.ncbi.nlm.nih.gov/pubmed/29541416
http://dx.doi.org/10.18632/oncotarget.24379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834252/
https://www.ncbi.nlm.nih.gov/pubmed/29541416
http://dx.doi.org/10.18632/oncotarget.24379

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