Targeting the cyclin dependent kinase and retinoblastoma axis overcomes standard of care resistance in BRAF(V600E)-mutant melanoma

Patient-derived tumor xenograft (PDTX) mouse models were used to discover new therapies for naïve and drug resistant BRAF(V600E)-mutant melanoma. Tumor histology, oncogenic protein expression, and antitumor activity were comparable between patient and PDTX-matched models thereby validating PDTXs as...

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Detalles Bibliográficos
Autores principales: Harris, Antoneicka L., Lee, Samantha E., Dawson, Louis K., Marlow, Laura A., Edenfield, Brandy H., Durham, William F., Flotte, Thomas J., Thompson, Michael, Small, Daniel L., Synnott, Aidan J., Markovic, Svetomir N., Copland, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834273/
https://www.ncbi.nlm.nih.gov/pubmed/29541385
http://dx.doi.org/10.18632/oncotarget.23649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834273/
https://www.ncbi.nlm.nih.gov/pubmed/29541385
http://dx.doi.org/10.18632/oncotarget.23649

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