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Inhibition of dihydrotestosterone synthesis in prostate cancer by combined frontdoor and backdoor pathway blockade

Androgen deprivation therapy (ADT) is palliative and prostate cancer (CaP) recurs as lethal castration-recurrent/resistant CaP (CRPC). One mechanism that provides CaP resistance to ADT is primary backdoor androgen metabolism, which uses up to four 3α-oxidoreductases to convert 5α-androstane-3α,17β-d...

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Detalles Bibliográficos
Autores principales:	Fiandalo, Michael V., Stocking, John J., Pop, Elena A., Wilton, John H., Mantione, Krystin M., Li, Yun, Attwood, Kristopher M., Azabdaftari, Gissou, Wu, Yue, Watt, David S., Wilson, Elizabeth M., Mohler, James L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834294/ https://www.ncbi.nlm.nih.gov/pubmed/29541409 http://dx.doi.org/10.18632/oncotarget.24107

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