Cargando…
Protective effects of PACAP in ischemia
Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Presence of PACAP and its specific receptor, PAC1, in the trigeminocervical complex, changes of...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834414/ https://www.ncbi.nlm.nih.gov/pubmed/29500688 http://dx.doi.org/10.1186/s10194-018-0845-3 |
_version_ | 1783303635558465536 |
---|---|
author | Reglodi, Dora Vaczy, Alexandra Rubio-Beltran, Eloísa MaassenVanDenBrink, Antoinette |
author_facet | Reglodi, Dora Vaczy, Alexandra Rubio-Beltran, Eloísa MaassenVanDenBrink, Antoinette |
author_sort | Reglodi, Dora |
collection | PubMed |
description | Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Presence of PACAP and its specific receptor, PAC1, in the trigeminocervical complex, changes of PACAP levels in migraine patients and the migraine-inducing effect of PACAP injection strongly support the involvement of PACAP/PAC1 receptor in migraine pathogenesis. While antagonizing PAC1 receptor is a promising therapeutic target in migraine, the diverse array of PACAP’s functions, including protection in ischemic events, requires that the cost-benefit of such an intervention is well investigated by taking all the beneficial effects of PACAP into account. In the present review we summarize the protective effects of PACAP in ischemia, especially in neuronal ischemic injuries, and discuss possible points to consider when developing strategies in migraine therapy interfering with the PACAP/PAC1 receptor system. |
format | Online Article Text |
id | pubmed-5834414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-58344142018-03-14 Protective effects of PACAP in ischemia Reglodi, Dora Vaczy, Alexandra Rubio-Beltran, Eloísa MaassenVanDenBrink, Antoinette J Headache Pain Review Article Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Presence of PACAP and its specific receptor, PAC1, in the trigeminocervical complex, changes of PACAP levels in migraine patients and the migraine-inducing effect of PACAP injection strongly support the involvement of PACAP/PAC1 receptor in migraine pathogenesis. While antagonizing PAC1 receptor is a promising therapeutic target in migraine, the diverse array of PACAP’s functions, including protection in ischemic events, requires that the cost-benefit of such an intervention is well investigated by taking all the beneficial effects of PACAP into account. In the present review we summarize the protective effects of PACAP in ischemia, especially in neuronal ischemic injuries, and discuss possible points to consider when developing strategies in migraine therapy interfering with the PACAP/PAC1 receptor system. Springer Milan 2018-03-02 /pmc/articles/PMC5834414/ /pubmed/29500688 http://dx.doi.org/10.1186/s10194-018-0845-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Article Reglodi, Dora Vaczy, Alexandra Rubio-Beltran, Eloísa MaassenVanDenBrink, Antoinette Protective effects of PACAP in ischemia |
title | Protective effects of PACAP in ischemia |
title_full | Protective effects of PACAP in ischemia |
title_fullStr | Protective effects of PACAP in ischemia |
title_full_unstemmed | Protective effects of PACAP in ischemia |
title_short | Protective effects of PACAP in ischemia |
title_sort | protective effects of pacap in ischemia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834414/ https://www.ncbi.nlm.nih.gov/pubmed/29500688 http://dx.doi.org/10.1186/s10194-018-0845-3 |
work_keys_str_mv | AT reglodidora protectiveeffectsofpacapinischemia AT vaczyalexandra protectiveeffectsofpacapinischemia AT rubiobeltraneloisa protectiveeffectsofpacapinischemia AT maassenvandenbrinkantoinette protectiveeffectsofpacapinischemia |