Cargando…
The Destiny of Glucose from a MicroRNA Perspective
Glucose serves as a primary, and for some tissues the unique, fuel source in order to generate and maintain the biological functions. Hyperglycemia is a hallmark of type 2 diabetes and is the direct consequence of perturbations in the glucose homeostasis. Insulin resistance, referred to as a reduced...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834423/ https://www.ncbi.nlm.nih.gov/pubmed/29535681 http://dx.doi.org/10.3389/fendo.2018.00046 |
_version_ | 1783303637739503616 |
---|---|
author | Mirra, Paola Nigro, Cecilia Prevenzano, Immacolata Leone, Alessia Raciti, Gregory Alexander Formisano, Pietro Beguinot, Francesco Miele, Claudia |
author_facet | Mirra, Paola Nigro, Cecilia Prevenzano, Immacolata Leone, Alessia Raciti, Gregory Alexander Formisano, Pietro Beguinot, Francesco Miele, Claudia |
author_sort | Mirra, Paola |
collection | PubMed |
description | Glucose serves as a primary, and for some tissues the unique, fuel source in order to generate and maintain the biological functions. Hyperglycemia is a hallmark of type 2 diabetes and is the direct consequence of perturbations in the glucose homeostasis. Insulin resistance, referred to as a reduced response of target tissues to the hormone, contributes to the development of hyperglycemia. The molecular mechanisms responsible for the altered glucose homeostasis are numerous and not completely understood. MicroRNAs (miRNAs) are now recognized as regulators of the lipid and glucose metabolism and are involved in the onset of metabolic diseases. Indeed, these small non-coding RNA molecules operate in the RNA silencing and posttranscriptional regulation of gene expression and may modulate the levels of kinases and enzymes in the glucose metabolism. Therefore, a better characterization of the function of miRNAs and a deeper understanding of their role in disease may represent a fundamental step toward innovative treatments addressing the causes, not only the symptoms, of hyperglycemia, using approaches aimed at restoring either miRNAs or their specific targets. In this review, we outline the current understanding regarding the impact of miRNAs in the glucose metabolism and highlight the need for further research focused on altered key kinases and enzymes in metabolic diseases. |
format | Online Article Text |
id | pubmed-5834423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58344232018-03-13 The Destiny of Glucose from a MicroRNA Perspective Mirra, Paola Nigro, Cecilia Prevenzano, Immacolata Leone, Alessia Raciti, Gregory Alexander Formisano, Pietro Beguinot, Francesco Miele, Claudia Front Endocrinol (Lausanne) Endocrinology Glucose serves as a primary, and for some tissues the unique, fuel source in order to generate and maintain the biological functions. Hyperglycemia is a hallmark of type 2 diabetes and is the direct consequence of perturbations in the glucose homeostasis. Insulin resistance, referred to as a reduced response of target tissues to the hormone, contributes to the development of hyperglycemia. The molecular mechanisms responsible for the altered glucose homeostasis are numerous and not completely understood. MicroRNAs (miRNAs) are now recognized as regulators of the lipid and glucose metabolism and are involved in the onset of metabolic diseases. Indeed, these small non-coding RNA molecules operate in the RNA silencing and posttranscriptional regulation of gene expression and may modulate the levels of kinases and enzymes in the glucose metabolism. Therefore, a better characterization of the function of miRNAs and a deeper understanding of their role in disease may represent a fundamental step toward innovative treatments addressing the causes, not only the symptoms, of hyperglycemia, using approaches aimed at restoring either miRNAs or their specific targets. In this review, we outline the current understanding regarding the impact of miRNAs in the glucose metabolism and highlight the need for further research focused on altered key kinases and enzymes in metabolic diseases. Frontiers Media S.A. 2018-02-26 /pmc/articles/PMC5834423/ /pubmed/29535681 http://dx.doi.org/10.3389/fendo.2018.00046 Text en Copyright © 2018 Mirra, Nigro, Prevenzano, Leone, Raciti, Formisano, Beguinot and Miele. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Mirra, Paola Nigro, Cecilia Prevenzano, Immacolata Leone, Alessia Raciti, Gregory Alexander Formisano, Pietro Beguinot, Francesco Miele, Claudia The Destiny of Glucose from a MicroRNA Perspective |
title | The Destiny of Glucose from a MicroRNA Perspective |
title_full | The Destiny of Glucose from a MicroRNA Perspective |
title_fullStr | The Destiny of Glucose from a MicroRNA Perspective |
title_full_unstemmed | The Destiny of Glucose from a MicroRNA Perspective |
title_short | The Destiny of Glucose from a MicroRNA Perspective |
title_sort | destiny of glucose from a microrna perspective |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834423/ https://www.ncbi.nlm.nih.gov/pubmed/29535681 http://dx.doi.org/10.3389/fendo.2018.00046 |
work_keys_str_mv | AT mirrapaola thedestinyofglucosefromamicrornaperspective AT nigrocecilia thedestinyofglucosefromamicrornaperspective AT prevenzanoimmacolata thedestinyofglucosefromamicrornaperspective AT leonealessia thedestinyofglucosefromamicrornaperspective AT racitigregoryalexander thedestinyofglucosefromamicrornaperspective AT formisanopietro thedestinyofglucosefromamicrornaperspective AT beguinotfrancesco thedestinyofglucosefromamicrornaperspective AT mieleclaudia thedestinyofglucosefromamicrornaperspective AT mirrapaola destinyofglucosefromamicrornaperspective AT nigrocecilia destinyofglucosefromamicrornaperspective AT prevenzanoimmacolata destinyofglucosefromamicrornaperspective AT leonealessia destinyofglucosefromamicrornaperspective AT racitigregoryalexander destinyofglucosefromamicrornaperspective AT formisanopietro destinyofglucosefromamicrornaperspective AT beguinotfrancesco destinyofglucosefromamicrornaperspective AT mieleclaudia destinyofglucosefromamicrornaperspective |