Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the world’s poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes...

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Detalles Bibliográficos
Autores principales: Norcliffe, Jennifer L., Mina, John G., Alvarez, Emilio, Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo, Valle, Silva Gonzalez-Del, Marco, Maria, Fiandor, José M., Martin, Julio J., Steel, Patrick G., Denny, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834442/
https://www.ncbi.nlm.nih.gov/pubmed/29500420
http://dx.doi.org/10.1038/s41598-018-22063-9

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