Cargando…

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets

Tuberculosis remains a serious threat to human health world-wide, and improved efficiency of medical treatment requires a better understanding of the pathogenesis and the discovery of new drugs. In the present study, we performed a whole-cell based screen in order to complete the characterization of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trofimov, Valentin, Kicka, Sébastien, Mucaria, Sabrina, Hanna, Nabil, Ramon-Olayo, Fernando, Del Peral, Laura Vela-Gonzalez, Lelièvre, Joël, Ballell, Lluís, Scapozza, Leonardo, Besra, Gurdyal S., Cox, Jonathan A. G., Soldati, Thierry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834492/ https://www.ncbi.nlm.nih.gov/pubmed/29500372 http://dx.doi.org/10.1038/s41598-018-22228-6

Ejemplares similares

Identification of Anti-Mycobacterium and Anti-Legionella Compounds With Potential Distinctive Structural Scaffolds From an HD-PBL Using Phenotypic Screens in Amoebae Host Models
por: Hanna, Nabil, et al.
Publicado: (2020)

Establishment and Validation of Whole-Cell Based Fluorescence Assays to Identify Anti-Mycobacterial Compounds Using the Acanthamoeba castellanii - Mycobacterium marinum Host-Pathogen System
por: Kicka, Sébastien, et al.
Publicado: (2014)

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen
por: Cox, Jonathan A. G., et al.
Publicado: (2016)

Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity
por: Dow, Mark, et al.
Publicado: (2017)

Mycobacterium tuberculosis Complex Mycobacteria as Amoeba-Resistant Organisms
por: Mba Medie, Felix, et al.
Publicado: (2011)

Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria
por: Rana, Amrita K., et al.
Publicado: (2012)

Editorial: Amoebae as Host Models to Study the Interaction With Pathogens
por: Thewes, Sascha, et al.
Publicado: (2019)

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
por: Batt, Sarah M., et al.
Publicado: (2020)

Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities
por: Wang, Pengxu, et al.
Publicado: (2021)

Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model
por: Ouertatani-Sakouhi, Hajer, et al.
Publicado: (2017)

Vanoxerine kills mycobacteria through membrane depolarization and efflux inhibition
por: Kingdon, Alexander D. H., et al.
Publicado: (2023)

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation
por: Mugumbate, Grace, et al.
Publicado: (2015)

Utilisation of the Prestwick Chemical Library to identify drugs that inhibit the growth of mycobacteria
por: Kanvatirth, Panchali, et al.
Publicado: (2019)

Antimycobacterial Activity of Hedeoma drummondii against Mycobacterium tuberculosis and Non-Tuberculous Mycobacteria
por: Molina-Torres, Carmen, et al.
Publicado: (2023)

Of Amoebae and Men: Extracellular DNA Traps as an Ancient Cell-Intrinsic Defense Mechanism
por: Zhang, Xuezhi, et al.
Publicado: (2016)

Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach
por: Soto, Ramón, et al.
Publicado: (2018)

Social amoebae trap and kill bacteria by casting DNA nets
por: Zhang, Xuezhi, et al.
Publicado: (2016)

Presence of Non-Tuberculous Mycobacteria Including Mycobacterium avium subsp. paratuberculosis Associated with Environmental Amoebae
por: Rochard, Vincent, et al.
Publicado: (2023)

In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay
por: Sankar, Manimuthu Mani, et al.
Publicado: (2008)

Exploring Anti-Bacterial Compounds against Intracellular Legionella
por: Harrison, Christopher F., et al.
Publicado: (2013)

MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria
por: Varela, Cristian, et al.
Publicado: (2012)

5-ethyl-2’-deoxyuridine fragilizes Klebsiella pneumoniae outer wall and facilitates intracellular killing by phagocytic cells
por: Ifrid, Estelle, et al.
Publicado: (2022)

IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria
por: Baumgart, Meike, et al.
Publicado: (2013)

Methods to Monitor and Quantify Autophagy in the Social Amoeba Dictyostelium discoideum
por: Domínguez-Martín, Eunice, et al.
Publicado: (2017)

INFECTIVE ORGANISMS IN THE CYTOPLASM OF AMOEBA PROTEUS
por: Roth, L. E., et al.
Publicado: (1961)

Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria
por: Alahari, Anuradha, et al.
Publicado: (2007)

Conidial Melanin of the Human-Pathogenic Fungus Aspergillus fumigatus Disrupts Cell Autonomous Defenses in Amoebae
por: Ferling, Iuliia, et al.
Publicado: (2020)

Amoebae as Potential Environmental Hosts for Mycobacterium ulcerans and Other Mycobacteria, but Doubtful Actors in Buruli Ulcer Epidemiology
por: Gryseels, Sophie, et al.
Publicado: (2012)

Novel Endosymbionts in Rhizarian Amoebae Imply Universal Infection of Unrelated Free-Living Amoebae by Legionellales
por: Solbach, Marcel Dominik, et al.
Publicado: (2021)

Crystal structure of the TreS:Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteria
por: Kermani, Ali A., et al.
Publicado: (2019)

Synthesis of α-Glucan in Mycobacteria Involves a Hetero-octameric Complex of Trehalose Synthase TreS and Maltokinase Pep2
por: Roy, Rana, et al.
Publicado: (2013)

When Dicty Met Myco, a (Not So) Romantic Story about One Amoeba and Its Intracellular Pathogen
por: Cardenal-Muñoz, Elena, et al.
Publicado: (2018)

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB
por: Abrahams, Katherine A., et al.
Publicado: (2012)

Diagnosis of Infections Caused by Pathogenic Free-Living Amoebae
por: da Rocha-Azevedo, Bruno, et al.
Publicado: (2009)

Review: Impact of Helminth Infection on Antimycobacterial Immunity—A Focus on the Macrophage
por: Lang, Roland, et al.
Publicado: (2017)

A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity
por: Ganapathy, Uday S., et al.
Publicado: (2021)

Synthesis of a Versatile Building Block for the Preparation of 6-N-Derivatized α-Galactosyl Ceramides: Rapid Access to Biologically Active Glycolipids
por: Jervis, Peter J., et al.
Publicado: (2010)

Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model
por: Erasto, Paul, et al.
Publicado: (2018)

Synthesis of N-substituted 2-[(1E)-alkenyl]-4-(1H)-quinolone derivatives as antimycobacterial agents against non-tubercular mycobacteria
por: Wube, Abraham A., et al.
Publicado: (2011)

Urinary Tract Infection with Atypical Mycobacteria
por: Thomas, Evan, et al.
Publicado: (1980)

Cannot write session to /tmp/vufind_sessions/sess_p1sij4c9rf40es2cataq81vshd