MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis

Matrix metalloproteinases are involved in vascular remodeling. Little is known about their immune regulatory role in atherosclerosis. Here we show that mice deficient for MT4-MMP have increased adherence of macrophages to inflamed peritonea, and larger lipid deposits and macrophage burden in atheros...

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Detalles Bibliográficos
Autores principales: Clemente, Cristina, Rius, Cristina, Alonso-Herranz, Laura, Martín-Alonso, Mara, Pollán, Ángela, Camafeita, Emilio, Martínez, Fernando, Mota, Rubén A., Núñez, Vanessa, Rodríguez, Cristina, Seiki, Motoharu, Martínez-González, José, Andrés, Vicente, Ricote, Mercedes, Arroyo, Alicia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834547/
https://www.ncbi.nlm.nih.gov/pubmed/29500407
http://dx.doi.org/10.1038/s41467-018-03351-4

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