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Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood
Recent research suggests that the incidence of amyotrophic lateral sclerosis (ALS) may be on the rise. Since ALS becomes predominant in later life, most studies on causal factors are conducted in middle-aged or older populations where potentially important influences from early life can usually not...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834569/ https://www.ncbi.nlm.nih.gov/pubmed/29285652 http://dx.doi.org/10.1007/s00415-017-8719-1 |
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author | Åberg, Maria Nyberg, Jenny Robertson, Josefina Kuhn, Georg Schiöler, Linus Nissbrandt, Hans Waern, Margda Torén, Kjell |
author_facet | Åberg, Maria Nyberg, Jenny Robertson, Josefina Kuhn, Georg Schiöler, Linus Nissbrandt, Hans Waern, Margda Torén, Kjell |
author_sort | Åberg, Maria |
collection | PubMed |
description | Recent research suggests that the incidence of amyotrophic lateral sclerosis (ALS) may be on the rise. Since ALS becomes predominant in later life, most studies on causal factors are conducted in middle-aged or older populations where potentially important influences from early life can usually not be adequately captured. We aimed to investigate predictors in young Swedish men for ALS in adulthood. Therefore, we performed a prospective cohort study of young men (aged 16–25, n = 1,819,817) who enlisted 1968–2005 and took part in comprehensive conscription examinations. Incident cases of ALS (n = 526) during up to 46 years of follow-up were identified in the National Hospital Register and Swedish Cause of Death Register. Those who developed ALS had lower BMI (body mass index) at conscription than their peers (p = 0.03). The risk of ALS during follow-up was calculated with Cox proportional hazards models. No associations were found with physical fitness, erythrocyte sedimentation rate, or non-psychotic mental disorders. Low overall muscle strength compared to high overall muscle strength [hazard ratio (HR) 1.36; 95% confidence interval (CI) 1.01–1.83] and low BMI (a one-unit increase HR 0.96; 95% CI 0.93–0.99) and lower erythrocyte volume fraction (a one-unit increase HR 0.96; 95% CI 0.92–0.998) were the statistically significant predictors for ALS in adjusted models. These findings provide novel epidemiologic evidence of a prospective association between low overall muscle strength and erythrocyte volume fraction in young men and ALS risk. |
format | Online Article Text |
id | pubmed-5834569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-58345692018-03-09 Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood Åberg, Maria Nyberg, Jenny Robertson, Josefina Kuhn, Georg Schiöler, Linus Nissbrandt, Hans Waern, Margda Torén, Kjell J Neurol Original Communication Recent research suggests that the incidence of amyotrophic lateral sclerosis (ALS) may be on the rise. Since ALS becomes predominant in later life, most studies on causal factors are conducted in middle-aged or older populations where potentially important influences from early life can usually not be adequately captured. We aimed to investigate predictors in young Swedish men for ALS in adulthood. Therefore, we performed a prospective cohort study of young men (aged 16–25, n = 1,819,817) who enlisted 1968–2005 and took part in comprehensive conscription examinations. Incident cases of ALS (n = 526) during up to 46 years of follow-up were identified in the National Hospital Register and Swedish Cause of Death Register. Those who developed ALS had lower BMI (body mass index) at conscription than their peers (p = 0.03). The risk of ALS during follow-up was calculated with Cox proportional hazards models. No associations were found with physical fitness, erythrocyte sedimentation rate, or non-psychotic mental disorders. Low overall muscle strength compared to high overall muscle strength [hazard ratio (HR) 1.36; 95% confidence interval (CI) 1.01–1.83] and low BMI (a one-unit increase HR 0.96; 95% CI 0.93–0.99) and lower erythrocyte volume fraction (a one-unit increase HR 0.96; 95% CI 0.92–0.998) were the statistically significant predictors for ALS in adjusted models. These findings provide novel epidemiologic evidence of a prospective association between low overall muscle strength and erythrocyte volume fraction in young men and ALS risk. Springer Berlin Heidelberg 2017-12-28 2018 /pmc/articles/PMC5834569/ /pubmed/29285652 http://dx.doi.org/10.1007/s00415-017-8719-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Communication Åberg, Maria Nyberg, Jenny Robertson, Josefina Kuhn, Georg Schiöler, Linus Nissbrandt, Hans Waern, Margda Torén, Kjell Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood |
title | Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood |
title_full | Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood |
title_fullStr | Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood |
title_full_unstemmed | Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood |
title_short | Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood |
title_sort | risk factors in swedish young men for amyotrophic lateral sclerosis in adulthood |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834569/ https://www.ncbi.nlm.nih.gov/pubmed/29285652 http://dx.doi.org/10.1007/s00415-017-8719-1 |
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