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Correction of Huntington’s Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model
Huntington’s disease (HD) is a monogenic disorder, caused by mutations in the HTT gene which result in expansion of CAG triplets. The product of the mutated gene is misfolded huntingtin protein that forms aggregates leading to impairment of neuronal function, neurodegeneration, motor abnormalities a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834590/ https://www.ncbi.nlm.nih.gov/pubmed/29435951 http://dx.doi.org/10.1007/s12017-018-8482-1 |