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Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generatio...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834599/ https://www.ncbi.nlm.nih.gov/pubmed/29500350 http://dx.doi.org/10.1038/s41467-018-03342-5 |
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author | Pierron, Denis Heiske, Margit Razafindrazaka, Harilanto Pereda-loth, Veronica Sanchez, Jazmin Alva, Omar Arachiche, Amal Boland, Anne Olaso, Robert Deleuze, Jean-Francois Ricaut, Francois-Xavier Rakotoarisoa, Jean-Aimé Radimilahy, Chantal Stoneking, Mark Letellier, Thierry |
author_facet | Pierron, Denis Heiske, Margit Razafindrazaka, Harilanto Pereda-loth, Veronica Sanchez, Jazmin Alva, Omar Arachiche, Amal Boland, Anne Olaso, Robert Deleuze, Jean-Francois Ricaut, Francois-Xavier Rakotoarisoa, Jean-Aimé Radimilahy, Chantal Stoneking, Mark Letellier, Thierry |
author_sort | Pierron, Denis |
collection | PubMed |
description | While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing power to detect selection. We analyze local ancestry across the genomes of 700 Malagasy and identify a strong signal of recent positive selection, with an estimated selection coefficient >0.2. The selection is for African ancestry and affects 25% of chromosome 1, including the Duffy blood group gene. The null allele at this gene provides resistance to Plasmodium vivax malaria, and previous studies have suggested positive selection for this allele in the Malagasy population. This selection event also influences numerous other genes implicated in immunity, cardiovascular diseases, and asthma and decreases the Asian ancestry genome-wide by 10%, illustrating the role played by selection in recent human history. |
format | Online Article Text |
id | pubmed-5834599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58345992018-03-06 Strong selection during the last millennium for African ancestry in the admixed population of Madagascar Pierron, Denis Heiske, Margit Razafindrazaka, Harilanto Pereda-loth, Veronica Sanchez, Jazmin Alva, Omar Arachiche, Amal Boland, Anne Olaso, Robert Deleuze, Jean-Francois Ricaut, Francois-Xavier Rakotoarisoa, Jean-Aimé Radimilahy, Chantal Stoneking, Mark Letellier, Thierry Nat Commun Article While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing power to detect selection. We analyze local ancestry across the genomes of 700 Malagasy and identify a strong signal of recent positive selection, with an estimated selection coefficient >0.2. The selection is for African ancestry and affects 25% of chromosome 1, including the Duffy blood group gene. The null allele at this gene provides resistance to Plasmodium vivax malaria, and previous studies have suggested positive selection for this allele in the Malagasy population. This selection event also influences numerous other genes implicated in immunity, cardiovascular diseases, and asthma and decreases the Asian ancestry genome-wide by 10%, illustrating the role played by selection in recent human history. Nature Publishing Group UK 2018-03-02 /pmc/articles/PMC5834599/ /pubmed/29500350 http://dx.doi.org/10.1038/s41467-018-03342-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pierron, Denis Heiske, Margit Razafindrazaka, Harilanto Pereda-loth, Veronica Sanchez, Jazmin Alva, Omar Arachiche, Amal Boland, Anne Olaso, Robert Deleuze, Jean-Francois Ricaut, Francois-Xavier Rakotoarisoa, Jean-Aimé Radimilahy, Chantal Stoneking, Mark Letellier, Thierry Strong selection during the last millennium for African ancestry in the admixed population of Madagascar |
title | Strong selection during the last millennium for African ancestry in the admixed population of Madagascar |
title_full | Strong selection during the last millennium for African ancestry in the admixed population of Madagascar |
title_fullStr | Strong selection during the last millennium for African ancestry in the admixed population of Madagascar |
title_full_unstemmed | Strong selection during the last millennium for African ancestry in the admixed population of Madagascar |
title_short | Strong selection during the last millennium for African ancestry in the admixed population of Madagascar |
title_sort | strong selection during the last millennium for african ancestry in the admixed population of madagascar |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834599/ https://www.ncbi.nlm.nih.gov/pubmed/29500350 http://dx.doi.org/10.1038/s41467-018-03342-5 |
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