Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis

PURPOSE: To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. OBSERVATIONS: Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonzales, John A., Shantha, Jessica, Acharya, Nisha R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Brief report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834645/
https://www.ncbi.nlm.nih.gov/pubmed/29511745
http://dx.doi.org/10.1016/j.ajoc.2018.02.005
_version_ 1783303691044913152
author Gonzales, John A.
Shantha, Jessica
Acharya, Nisha R.
author_facet Gonzales, John A.
Shantha, Jessica
Acharya, Nisha R.
author_sort Gonzales, John A.
collection PubMed
description PURPOSE: To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. OBSERVATIONS: Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary discontinuation of nivolumab and cabiralizumab as well as systemic prednisone. CONCLUSIONS AND IMPORTANCE: Ophthalmologists should be aware of the possibility of acute ocular inflammation developing with cancer immunotherapy. Systemic corticosteroids play a first-line role in managing such immune-mediated side effects.
format Online
Article
Text
id pubmed-5834645
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-58346452018-03-06 Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis Gonzales, John A. Shantha, Jessica Acharya, Nisha R. Am J Ophthalmol Case Rep Brief report PURPOSE: To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. OBSERVATIONS: Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary discontinuation of nivolumab and cabiralizumab as well as systemic prednisone. CONCLUSIONS AND IMPORTANCE: Ophthalmologists should be aware of the possibility of acute ocular inflammation developing with cancer immunotherapy. Systemic corticosteroids play a first-line role in managing such immune-mediated side effects. Elsevier 2018-02-08 /pmc/articles/PMC5834645/ /pubmed/29511745 http://dx.doi.org/10.1016/j.ajoc.2018.02.005 Text en © 2018 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief report
Gonzales, John A.
Shantha, Jessica
Acharya, Nisha R.
Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
title Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
title_full Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
title_fullStr Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
title_full_unstemmed Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
title_short Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
title_sort combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
topic Brief report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834645/
https://www.ncbi.nlm.nih.gov/pubmed/29511745
http://dx.doi.org/10.1016/j.ajoc.2018.02.005
work_keys_str_mv AT gonzalesjohna combinationnivolumabandcabiralizumabassociatedacutebilateralanteriorandposteriorscleritisandanterioruveitis
AT shanthajessica combinationnivolumabandcabiralizumabassociatedacutebilateralanteriorandposteriorscleritisandanterioruveitis
AT acharyanishar combinationnivolumabandcabiralizumabassociatedacutebilateralanteriorandposteriorscleritisandanterioruveitis

Ejemplares similares