Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

Chimeric antigen receptor T (CAR-T) cells are effective serial killers with a faster off-rate from dying tumor cells than CAR-T cells binding target cells through their T cell receptor (TCR). Here we explored the functional consequences of CAR-mediated signaling using a dual-specific CAR-T cell, whe...

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Detalles Bibliográficos
Autores principales: Davenport, A. J., Cross, R. S., Watson, K. A., Liao, Y., Shi, W., Prince, H. M., Beavis, P. A., Trapani, J. A., Kershaw, M. H., Ritchie, D. S., Darcy, P. K., Neeson, P. J., Jenkins, M. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834689/
https://www.ncbi.nlm.nih.gov/pubmed/29440406
http://dx.doi.org/10.1073/pnas.1716266115

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