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The ZBED6–IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals
A single nucleotide substitution in the third intron of insulin-like growth factor 2 (IGF2) is associated with increased muscle mass and reduced subcutaneous fat in domestic pigs. This mutation disrupts the binding of the ZBED6 transcription factor and leads to a threefold up-regulation of IGF2 expr...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834713/ https://www.ncbi.nlm.nih.gov/pubmed/29440408 http://dx.doi.org/10.1073/pnas.1719278115 |