Cargando…
New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin‐like growth factor/AKT/mammalian target of rapamycin pathways
Metformin is a biguanide widely prescribed as an antidiabetic drug for type 2 diabetes mellitus patients. The purpose of the present study was to observe the effects of the new metformin derivative, HL156A, on human oral cancer cell and to investigate its possible mechanisms. It was observed that HL...
Autores principales: | Lam, Thuy Giang, Jeong, Yun Soo, Kim, Soo‐A, Ahn, Sang‐Gun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834796/ https://www.ncbi.nlm.nih.gov/pubmed/29285837 http://dx.doi.org/10.1111/cas.13482 |
Ejemplares similares
-
Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice
por: Kim, Soo-A, et al.
Publicado: (2018) -
Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells
por: Jeong, Yun Soo, et al.
Publicado: (2020) -
The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
por: Yoon, Mee-Sup
Publicado: (2017) -
The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
por: Yoon, Mee-Sup, et al.
Publicado: (2016) -
Towards natural mimetics of metformin and rapamycin
por: Aliper, Alexander, et al.
Publicado: (2017)