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Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry

All isocitrate dehydrogenase (IDH) mutant solid neoplasms exhibit highly elevated levels of D-2-hydroxyglutarate (D-2HG). Detection of 2HG in tumor tissues currently is performed by gas or liquid chromatography-mass spectrometry (GC- or LC-MS) or biochemical detection. While these methods are highly...

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Detalles Bibliográficos
Autores principales:	Longuespée, Rémi, Wefers, Annika K., De Vita, Elena, Miller, Aubry K., Reuss, David E., Wick, Wolfgang, Herold-Mende, Christel, Kriegsmann, Mark, Schirmacher, Peter, von Deimling, Andreas, Pusch, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834865/ https://www.ncbi.nlm.nih.gov/pubmed/29499756 http://dx.doi.org/10.1186/s40478-018-0523-3

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