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Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study

BACKGROUND: The oldest old generally have worse health and more comorbidities than the general population of older adults, and they are more likely to be exposed to polypharmacy. Reliable investigation of polypharmacy among the oldest old (≥80 years of age) in China are lacking. So this study aims t...

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Autores principales: Lai, Xiaoxing, Zhu, Hongwei, Huo, Xiaopeng, Li, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834886/
https://www.ncbi.nlm.nih.gov/pubmed/29499639
http://dx.doi.org/10.1186/s12877-018-0754-y
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author Lai, Xiaoxing
Zhu, Hongwei
Huo, Xiaopeng
Li, Zheng
author_facet Lai, Xiaoxing
Zhu, Hongwei
Huo, Xiaopeng
Li, Zheng
author_sort Lai, Xiaoxing
collection PubMed
description BACKGROUND: The oldest old generally have worse health and more comorbidities than the general population of older adults, and they are more likely to be exposed to polypharmacy. Reliable investigation of polypharmacy among the oldest old (≥80 years of age) in China are lacking. So this study aims to describe the polypharmacy status of oldest old patients ≥80 years of age and to assess the factors influencing medication compliance. METHODS: This was a cross-sectional study of 258 oldest old patients ≥ 80 years of age and hospitalized at a tertiary hospital in Beijing between December 1, 2014 and June 30, 2015. They completed three validated questionnaires to assess their pre-admission status (general demographics, medication knowledge, and medication adherence). Potentially inappropriate medications (PIM) use was evaluated by physicians. RESULTS: The majority of the patients (55.4%) took < 10 types of drugs. The numbers of drugs taken ranged from 8 to 60 drugs (median of 22.9). Patients taking 11–20 drugs accounted for 46.1% of the patients. Subjects with a history of adverse drug reactions accounted for 40.3%. The proportion of PIMs was 27.1%. Compliance was only 32.6% among the oldest old patients with polypharmacy. Age and medication classes were independently negatively associated with compliance, and medication knowledge was independently positively associated with compliance. CONCLUSION: Oldest old patients (≥ 80 years of age) had a poor medication knowledge. Age, medication classes, and medication knowledge were independently associated with medication compliance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-018-0754-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-58348862018-03-05 Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study Lai, Xiaoxing Zhu, Hongwei Huo, Xiaopeng Li, Zheng BMC Geriatr Research Article BACKGROUND: The oldest old generally have worse health and more comorbidities than the general population of older adults, and they are more likely to be exposed to polypharmacy. Reliable investigation of polypharmacy among the oldest old (≥80 years of age) in China are lacking. So this study aims to describe the polypharmacy status of oldest old patients ≥80 years of age and to assess the factors influencing medication compliance. METHODS: This was a cross-sectional study of 258 oldest old patients ≥ 80 years of age and hospitalized at a tertiary hospital in Beijing between December 1, 2014 and June 30, 2015. They completed three validated questionnaires to assess their pre-admission status (general demographics, medication knowledge, and medication adherence). Potentially inappropriate medications (PIM) use was evaluated by physicians. RESULTS: The majority of the patients (55.4%) took < 10 types of drugs. The numbers of drugs taken ranged from 8 to 60 drugs (median of 22.9). Patients taking 11–20 drugs accounted for 46.1% of the patients. Subjects with a history of adverse drug reactions accounted for 40.3%. The proportion of PIMs was 27.1%. Compliance was only 32.6% among the oldest old patients with polypharmacy. Age and medication classes were independently negatively associated with compliance, and medication knowledge was independently positively associated with compliance. CONCLUSION: Oldest old patients (≥ 80 years of age) had a poor medication knowledge. Age, medication classes, and medication knowledge were independently associated with medication compliance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-018-0754-y) contains supplementary material, which is available to authorized users. BioMed Central 2018-03-02 /pmc/articles/PMC5834886/ /pubmed/29499639 http://dx.doi.org/10.1186/s12877-018-0754-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lai, Xiaoxing
Zhu, Hongwei
Huo, Xiaopeng
Li, Zheng
Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study
title Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study
title_full Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study
title_fullStr Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study
title_full_unstemmed Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study
title_short Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study
title_sort polypharmacy in the oldest old (≥80 years of age) patients in china: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834886/
https://www.ncbi.nlm.nih.gov/pubmed/29499639
http://dx.doi.org/10.1186/s12877-018-0754-y
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