Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link

BACKGROUND: Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be related to ischemic vascular events. CASE PRESENTATION: Herein, we report for th...

Descripción completa

Detalles Bibliográficos
Autores principales: Sachak, Taha, Heerema, Nyla A., Mayerson, Joel, Payne, Jason E., Parwani, Anil, Iwenofu, O. Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834908/
https://www.ncbi.nlm.nih.gov/pubmed/29499721
http://dx.doi.org/10.1186/s13000-018-0695-y
_version_ 1783303734969761792
author Sachak, Taha
Heerema, Nyla A.
Mayerson, Joel
Payne, Jason E.
Parwani, Anil
Iwenofu, O. Hans
author_facet Sachak, Taha
Heerema, Nyla A.
Mayerson, Joel
Payne, Jason E.
Parwani, Anil
Iwenofu, O. Hans
author_sort Sachak, Taha
collection PubMed
description BACKGROUND: Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be related to ischemic vascular events. CASE PRESENTATION: Herein, we report for the first time, two cytogenetic translocations, t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) in a 75 year-old ambulating female with a history of left total hip arthroplasty 20 years ago. CONCLUSION: These translocations suggest a possible clonal pathogenetic link though their significance remains to be established.
format Online
Article
Text
id pubmed-5834908
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-58349082018-03-05 Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link Sachak, Taha Heerema, Nyla A. Mayerson, Joel Payne, Jason E. Parwani, Anil Iwenofu, O. Hans Diagn Pathol Case Report BACKGROUND: Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be related to ischemic vascular events. CASE PRESENTATION: Herein, we report for the first time, two cytogenetic translocations, t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) in a 75 year-old ambulating female with a history of left total hip arthroplasty 20 years ago. CONCLUSION: These translocations suggest a possible clonal pathogenetic link though their significance remains to be established. BioMed Central 2018-03-02 /pmc/articles/PMC5834908/ /pubmed/29499721 http://dx.doi.org/10.1186/s13000-018-0695-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Sachak, Taha
Heerema, Nyla A.
Mayerson, Joel
Payne, Jason E.
Parwani, Anil
Iwenofu, O. Hans
Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link
title Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link
title_full Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link
title_fullStr Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link
title_full_unstemmed Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link
title_short Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link
title_sort novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834908/
https://www.ncbi.nlm.nih.gov/pubmed/29499721
http://dx.doi.org/10.1186/s13000-018-0695-y
work_keys_str_mv AT sachaktaha novelt12p361q23andt719q32q133chromosomaltranslocationsinischemicfasciitisexpandingthespectrumofpseudosarcomatouslesionswithclonalpathogeneticlink
AT heeremanylaa novelt12p361q23andt719q32q133chromosomaltranslocationsinischemicfasciitisexpandingthespectrumofpseudosarcomatouslesionswithclonalpathogeneticlink
AT mayersonjoel novelt12p361q23andt719q32q133chromosomaltranslocationsinischemicfasciitisexpandingthespectrumofpseudosarcomatouslesionswithclonalpathogeneticlink
AT paynejasone novelt12p361q23andt719q32q133chromosomaltranslocationsinischemicfasciitisexpandingthespectrumofpseudosarcomatouslesionswithclonalpathogeneticlink
AT parwanianil novelt12p361q23andt719q32q133chromosomaltranslocationsinischemicfasciitisexpandingthespectrumofpseudosarcomatouslesionswithclonalpathogeneticlink
AT iwenofuohans novelt12p361q23andt719q32q133chromosomaltranslocationsinischemicfasciitisexpandingthespectrumofpseudosarcomatouslesionswithclonalpathogeneticlink

Ejemplares similares