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Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy

Activated PI3 kinase delta syndrome (APDS) is a primary immunodeficiency caused by dominant mutations that increase activity of phosphoinositide-3-kinase δ (PI3Kδ). APDS can be caused by mutations in the PIK3CD gene that encodes PI3Kδ catalytic subunit p110δ (APDS1) or mutations in the PIK3R1 gene t...

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Detalles Bibliográficos
Autores principales:	Michalovich, David, Nejentsev, Sergey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835040/ https://www.ncbi.nlm.nih.gov/pubmed/29535736 http://dx.doi.org/10.3389/fimmu.2018.00369

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