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Feasibility of a Conditional Knockout System for Chlamydia Based on CRISPR Interference
Chlamydia is an obligate intracellular bacterium and, as such, has significantly reduced its genome size and content. Although recent advances have allowed for transformation of C. trachomatis with an exogenous plasmid, genetic manipulation of Chlamydia remains challenging. In particular, the abilit...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835046/ https://www.ncbi.nlm.nih.gov/pubmed/29535977 http://dx.doi.org/10.3389/fcimb.2018.00059 |