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A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases
The objective of this study is to examine 25-hydroxyvitamin D [25(OH)D] (D-25) levels and associations with patient- and disease-related factors in rheumatic diseases. This is a register-based study of D-25 levels in adult patients seen at the Central Finland Hospital rheumatology clinic (January 20...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer London
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835053/ https://www.ncbi.nlm.nih.gov/pubmed/29116541 http://dx.doi.org/10.1007/s10067-017-3870-8 |
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author | Nikiphorou, Elena Uksila, Jaakko Sokka, Tuulikki |
author_facet | Nikiphorou, Elena Uksila, Jaakko Sokka, Tuulikki |
author_sort | Nikiphorou, Elena |
collection | PubMed |
description | The objective of this study is to examine 25-hydroxyvitamin D [25(OH)D] (D-25) levels and associations with patient- and disease-related factors in rheumatic diseases. This is a register-based study of D-25 levels in adult patients seen at the Central Finland Hospital rheumatology clinic (January 2011–April 2015). Demographic, clinical, laboratory, and patient-reported outcomes (PROs) were collected as part of the normal infrastructure of the outpatient clinic and examined for their association with D-25 level. Statistical analysis included descriptive statistics and univariable and multivariable regression analyses adjusting for age and gender. D-25 was measured in 3203 patients (age range 15–91 years, mean 54; 68% female) with diagnoses including RA (n = 1386), unspecified arthralgia/myalgia (n = 413), and connective tissues diseases (n = 213). The overall D-25 mean (SD) level was 78 (31) and median (IQR) 75 (55, 97). At baseline, 17.8% had D-25 deficiency, and only 1.6% severe deficiency (< 25 nmol/l); 34%/49% had sufficient/optimal D-25 levels. Higher D-25 levels were associated with older age, lower BMI, and regular exercise (all p < 0.001) among other factors. In multivariable analyses, younger age, non-white background, higher BMI, smoking, less frequent exercise (p < 0.001), and first visit to the clinic (p = 0.033) remained significantly associated with D-25 deficiency. Among those with sub-optimal D-25 levels, 64% had improved to sufficient/optimal levels after a median (IQR) of 13 (7.8, 22) months. The proportion of patients with D-25 deficiency in this study was generally low. Older patients had considerably higher D-25 levels compared to younger patients. Lower physical exercise and higher BMI were associated with higher risk of deficiency. The study supports the benefit of strategies to help minimize the risk of D-25 deficiency. |
format | Online Article Text |
id | pubmed-5835053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer London |
record_format | MEDLINE/PubMed |
spelling | pubmed-58350532018-03-09 A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases Nikiphorou, Elena Uksila, Jaakko Sokka, Tuulikki Clin Rheumatol Brief Report The objective of this study is to examine 25-hydroxyvitamin D [25(OH)D] (D-25) levels and associations with patient- and disease-related factors in rheumatic diseases. This is a register-based study of D-25 levels in adult patients seen at the Central Finland Hospital rheumatology clinic (January 2011–April 2015). Demographic, clinical, laboratory, and patient-reported outcomes (PROs) were collected as part of the normal infrastructure of the outpatient clinic and examined for their association with D-25 level. Statistical analysis included descriptive statistics and univariable and multivariable regression analyses adjusting for age and gender. D-25 was measured in 3203 patients (age range 15–91 years, mean 54; 68% female) with diagnoses including RA (n = 1386), unspecified arthralgia/myalgia (n = 413), and connective tissues diseases (n = 213). The overall D-25 mean (SD) level was 78 (31) and median (IQR) 75 (55, 97). At baseline, 17.8% had D-25 deficiency, and only 1.6% severe deficiency (< 25 nmol/l); 34%/49% had sufficient/optimal D-25 levels. Higher D-25 levels were associated with older age, lower BMI, and regular exercise (all p < 0.001) among other factors. In multivariable analyses, younger age, non-white background, higher BMI, smoking, less frequent exercise (p < 0.001), and first visit to the clinic (p = 0.033) remained significantly associated with D-25 deficiency. Among those with sub-optimal D-25 levels, 64% had improved to sufficient/optimal levels after a median (IQR) of 13 (7.8, 22) months. The proportion of patients with D-25 deficiency in this study was generally low. Older patients had considerably higher D-25 levels compared to younger patients. Lower physical exercise and higher BMI were associated with higher risk of deficiency. The study supports the benefit of strategies to help minimize the risk of D-25 deficiency. Springer London 2017-11-07 2018 /pmc/articles/PMC5835053/ /pubmed/29116541 http://dx.doi.org/10.1007/s10067-017-3870-8 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Brief Report Nikiphorou, Elena Uksila, Jaakko Sokka, Tuulikki A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases |
title | A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases |
title_full | A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases |
title_fullStr | A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases |
title_full_unstemmed | A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases |
title_short | A cross-sectional study of vitamin D levels in a large cohort of patients with rheumatic diseases |
title_sort | cross-sectional study of vitamin d levels in a large cohort of patients with rheumatic diseases |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835053/ https://www.ncbi.nlm.nih.gov/pubmed/29116541 http://dx.doi.org/10.1007/s10067-017-3870-8 |
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