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Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT(1A) Receptor Stimulation in Male Rats

Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive “spice” products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5-HT(2A/2C) receptor function in the brain, an effect which mig...

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Detalles Bibliográficos
Autores principales:	Elmore, Joshua S., Baumann, Michael H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835089/ https://www.ncbi.nlm.nih.gov/pubmed/29535650 http://dx.doi.org/10.3389/fpsyt.2018.00055

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