Cargando…

Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT(1A) Receptor Stimulation in Male Rats

Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive “spice” products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5-HT(2A/2C) receptor function in the brain, an effect which mig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elmore, Joshua S., Baumann, Michael H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835089/ https://www.ncbi.nlm.nih.gov/pubmed/29535650 http://dx.doi.org/10.3389/fpsyt.2018.00055

Ejemplares similares

Psychostimulant Effect of the Synthetic Cannabinoid JWH-018 and AKB48: Behavioral, Neurochemical, and Dopamine Transporter Scan Imaging Studies in Mice
por: Ossato, Andrea, et al.
Publicado: (2017)

Data on individual metabolites of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans
por: Watanabe, Shimpei, et al.
Publicado: (2016)

Self-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats
por: Hiranita, Takato
Publicado: (2015)

Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner
por: Izquierdo-Luengo, Cristina, et al.
Publicado: (2023)

Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory
por: Li, Ren-shi, et al.
Publicado: (2019)

In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice
por: Tirri, Micaela, et al.
Publicado: (2022)

Natural (∆(9)-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB(1) receptor
por: Malyshevskaya, Olga, et al.
Publicado: (2017)

Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice
por: Margiani, Giulia, et al.
Publicado: (2022)

Neurocognition and Subjective Experience Following Acute Doses of the Synthetic Cannabinoid JWH-018: Responders Versus Nonresponders
por: Theunissen, Eef L., et al.
Publicado: (2019)

Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018): implications for psychosis
por: Theunissen, Eef L., et al.
Publicado: (2021)

Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210
por: Cha, Hye Jin, et al.
Publicado: (2015)

Correction to: Adolescent self‑administration of the synthetic cannabinoid receptor agonist JWH‑018 induces neurobiological and behavioral alterations in adult male mice
por: Margiani, Giulia, et al.
Publicado: (2023)

Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
por: Brents, Lisa K., et al.
Publicado: (2011)

Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176
por: Tampus, Reinholdgher, et al.
Publicado: (2015)

Synthetic cannabinoid JWH-073 alters both acute behavior and in vivo/vitro electrophysiological responses in mice
por: Barbieri, Mario, et al.
Publicado: (2022)

Repeated exposure to JWH‐018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates
por: Pintori, Nicholas, et al.
Publicado: (2021)

Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches
por: Cha, Hye Jin, et al.
Publicado: (2014)

Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression
por: Sayson, Leandro Val, et al.
Publicado: (2023)

Behavioral Effects of Developmental Exposure to JWH-018 in Wild-Type and Disrupted in Schizophrenia 1 (disc1) Mutant Zebrafish
por: García-González, Judit, et al.
Publicado: (2021)

Behavioral and Pharmacokinetic Profile of Indole-Derived Synthetic Cannabinoids JWH-073 and JWH-210 as Compared to the Phytocannabinoid Δ(9)-THC in Rats
por: Uttl, Libor, et al.
Publicado: (2018)

Acute Cardiovascular and Cardiorespiratory Effects of JWH-018 in Awake and Freely Moving Mice: Mechanism of Action and Possible Antidotal Interventions?
por: Marchetti, Beatrice, et al.
Publicado: (2023)

Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study
por: Martínez, Lucia, et al.
Publicado: (2021)

Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS
por: La Maida, Nunzia, et al.
Publicado: (2020)

The Old and the New: Cardiovascular and Respiratory Alterations Induced by Acute JWH-018 Administration Compared to Δ(9)-THC—A Preclinical Study in Mice
por: Marchetti, Beatrice, et al.
Publicado: (2023)

Prenatal Cannabinoid Exposure: Emerging Evidence of Physiological and Neuropsychiatric Abnormalities
por: Nashed, Mina G., et al.
Publicado: (2021)

Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice
por: Fu, Qiang, et al.
Publicado: (2017)

Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and ∆ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs
por: Schaefer, Nadine, et al.
Publicado: (2017)

Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice
por: Hess, Cornelius, et al.
Publicado: (2016)

Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
por: Hanlon, Katherine E, et al.
Publicado: (2016)

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018
por: Finlay, David B., et al.
Publicado: (2022)

Treatment of Spider Phobia Using Repeated Exposures and Adjunctive Repetitive Transcranial Magnetic Stimulation: A Proof-of-Concept Study
por: Leuchter, Michael K., et al.
Publicado: (2022)

Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB(2)
por: Olea-Herrero, N, et al.
Publicado: (2009)

PM291. Synthetic cannabinoid JWH-210 induces motor impairments through the regulation of neurotransmission in tetanus toxin-treated mice
por: Yun, Jaesuk, et al.
Publicado: (2016)

Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages
por: Rosario-Rodríguez, Lester J., et al.
Publicado: (2022)

Toxicity of Synthetic Cannabinoids in K2/Spice: A Systematic Review
por: de Oliveira, Mariana Campello, et al.
Publicado: (2023)

Prospects for the Use of Cannabinoids in Psychiatric Disorders
por: Graczyk, Michał, et al.
Publicado: (2021)

Radiation Tolerant Design with 0.18-micron CMOS Technology
por: Chen, Li
Publicado: (2017)

Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors
por: Mannekote Thippaiah, Srinagesh, et al.
Publicado: (2021)

The e-Psychonauts’ ‘Spiced’ World; Assessment of the Synthetic  Cannabinoids’ Information Available Online
por: Zangani, Caroline, et al.
Publicado: (2020)

Lateral flow immunoassay and enzyme linked immunosorbent assay as effective immunomethods for the detection of synthetic cannabinoid JWH-200 based on the newly synthesized hapten
por: Fojtíková, Lucie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3mg835d9s53vitgbu6ffo8be53