Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells

The ability to engineer primary human B cells to differentiate into long-lived plasma cells and secrete a de novo protein may allow the creation of novel plasma cell therapies for protein deficiency diseases and other clinical applications. We initially developed methods for efficient genome editing...

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Detalles Bibliográficos
Autores principales: Hung, King L., Meitlis, Iana, Hale, Malika, Chen, Chun-Yu, Singh, Swati, Jackson, Shaun W., Miao, Carol H., Khan, Iram F., Rawlings, David J., James, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835153/
https://www.ncbi.nlm.nih.gov/pubmed/29273498
http://dx.doi.org/10.1016/j.ymthe.2017.11.012

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