Cargando…

6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells

Gingerols, the pungent ingredients in ginger, are reported to possess a cholesterol-lowering activity. However, the underlying mechanism remains unclear. The present study was to investigate how 6-gingerol (6-GN), the most abundant gingerol in fresh ginger, regulates hepatic cholesterol metabolism....

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiao, Guo, Jingting, Liang, Ning, Jiang, Xinwei, Song, Yuan, Ou, Shiyi, Hu, Yunfeng, Jiao, Rui, Bai, Weibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835308/ https://www.ncbi.nlm.nih.gov/pubmed/29535632 http://dx.doi.org/10.3389/fphar.2018.00159

Ejemplares similares

Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells
por: Yuan, Yangbing, et al.
Publicado: (2023)

The Cholesterol-Modulating Effect of Methanol Extract of Pigeon Pea (Cajanus cajan (L.) Millsp.) Leaves on Regulating LDLR and PCSK9 Expression in HepG2 Cells
por: Chang, Heng-Yuan, et al.
Publicado: (2019)

Cholesterol-lowing effect of taurine in HepG2 cell
por: Guo, Junxia, et al.
Publicado: (2017)

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration
por: Liang, Ning, et al.
Publicado: (2021)

Cyanidin-3-O-Glucoside Protects against 1,3-Dichloro-2-Propanol-Induced Reduction of Progesterone by Up-regulation of Steroidogenic Enzymes and cAMP Level in Leydig Cells
por: Sun, Jianxia, et al.
Publicado: (2016)

Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells
por: Leng, Ennian, et al.
Publicado: (2018)

Lavender Essential Oil Modulates Hepatic Cholesterol Metabolism in HepG2 Cells
por: Martella, Noemi, et al.
Publicado: (2023)

α-Synuclein Regulates Neuronal Cholesterol Efflux
por: Hsiao, Jen-Hsiang T., et al.
Publicado: (2017)

Cholesterol metabolism in the regulation of inflammatory responses
por: Bauer, Rebekka, et al.
Publicado: (2023)

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells
por: Grünig, David, et al.
Publicado: (2018)

Effects of dehydroabietic acid on nontarget lipidomics and proteomics of HepG2
por: Xiahou, Zhikai, et al.
Publicado: (2022)

Targeted cholesterol efflux
por: Fang, Longhou, et al.
Publicado: (2013)

Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway
por: Zhu, Hongtian, et al.
Publicado: (2019)

New insights into the regulation of cholesterol efflux from the sperm membrane
por: Leahy, Tamara, et al.
Publicado: (2015)

Substrate Stiffness Regulates Cholesterol Efflux in Smooth Muscle Cells
por: Mao, Xiuli, et al.
Publicado: (2021)

PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2
por: Strahm, Emmanuel, et al.
Publicado: (2014)

Allicin and Capsaicin Ameliorated Hypercholesterolemia by Upregulating LDLR and Downregulating PCSK9 Expression in HepG2 Cells
por: Nawaka, Nantiya, et al.
Publicado: (2022)

MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes
por: Kostopoulou, Fotini, et al.
Publicado: (2015)

Physicochemical Properties and Effects of Honeys on Key Biomarkers of Oxidative Stress and Cholesterol Homeostasis in HepG2 Cells
por: Nguyen, Huong Thi Lan, et al.
Publicado: (2021)

Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells
por: Huang, Yunying, et al.
Publicado: (2021)

Cis- and Trans-Palmitoleic Acid Isomers Regulate Cholesterol Metabolism in Different Ways
por: Huang, Wen-wen, et al.
Publicado: (2020)

Combined Use of Astragalus Polysaccharide and Berberine Attenuates Insulin Resistance in IR-HepG2 Cells via Regulation of the Gluconeogenesis Signaling Pathway
por: Mao, Zhu-Jun, et al.
Publicado: (2019)

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis
por: Li, Hong, et al.
Publicado: (2019)

Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
por: Zhang, Xinyuan, et al.
Publicado: (2021)

β(3)-Adrenoceptor activation upregulates apolipoprotein A-I expression in HepG2 cells, which might further promote cholesterol efflux from macrophage foam cells
por: Gao, Xia-qing, et al.
Publicado: (2017)

Carvedilol Ameliorates Experimental Atherosclerosis by Regulating Cholesterol Efflux and Exosome Functions
por: Chen, Sy-Jou, et al.
Publicado: (2019)

Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients
por: Dong, Yubing, et al.
Publicado: (2021)

Tanshinone IIA alleviates atherosclerosis in LDLR(−/−) mice by regulating efferocytosis of macrophages
por: Wang, Jiarou, et al.
Publicado: (2023)

Triterpenoids from Protorhus longifolia Exhibit Hypocholesterolemic Potential via Regulation of Cholesterol Biosynthesis and Stimulation of Low-Density Lipoprotein Uptake in HepG2 Cells
por: Ndlovu, Musawenkosi, et al.
Publicado: (2023)

Transcriptome Analyses of the Anti-Proliferative Effects of 20(S)-Ginsenoside Rh2 on HepG2 Cells
por: Zhang, Ji, et al.
Publicado: (2019)

Molecular Mechanisms of Cellular Cholesterol Efflux
por: Phillips, Michael C.
Publicado: (2014)

Cholesterol efflux pathways, inflammation, and atherosclerosis
por: Groenen, Anouk G., et al.
Publicado: (2021)

HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4(+) T cell activation in Sjögren’s syndrome
por: Yin, Junhao, et al.
Publicado: (2023)

Effects of the Phytochemical Combination PB123 on Nrf2 Activation, Gene Expression, and the Cholesterol Pathway in HepG2 Cells
por: Hybertson, Brooks M., et al.
Publicado: (2022)

4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters
por: Salonurmi, Tuire, et al.
Publicado: (2020)

Retinoid regulated macrophage cholesterol efflux involves the steroidogenic acute regulatory protein
por: Manna, Pulak R.
Publicado: (2016)

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
por: Sallam, Tamer, et al.
Publicado: (2018)

Low-Density Lipoprotein Receptor (LDLR) Family Orchestrates Cholesterol Homeostasis
por: Go, Gwang-woong, et al.
Publicado: (2012)

High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells
por: Rondón-Ortiz, Alejandro N., et al.
Publicado: (2017)

Lycorine Induces Mitochondria-Dependent Apoptosis in Hepatoblastoma HepG2 Cells Through ROCK1 Activation
por: Liu, Wu-yi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_91nalr22jdqscn3qk6n4vsjdr0