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T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response

Class IA phosphatidylinositol 3-kinase (PI3K) catalytic subunits p110α and p110δ are targets in cancer therapy expressed at high levels in T lymphocytes. The role of p110δ PI3K in normal or pathological immune responses is well established, yet the importance of p110α subunits in T cell-dependent im...

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Detalles Bibliográficos
Autores principales:	Aragoneses-Fenoll, Laura, Ojeda, Gloria, Montes-Casado, María, Acosta-Ampudia, Yeny, Dianzani, Umberto, Portolés, Pilar, Rojo, José M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835342/ https://www.ncbi.nlm.nih.gov/pubmed/29535720 http://dx.doi.org/10.3389/fimmu.2018.00332

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