Cargando…

CD99: A potential Diagnostic Marker for Differentiating Sub-ependymal Giant Cell Astrocytoma From Other Mimickers: A Report of Five Cases

BACKGROUND: Tuberous sclerosis (TSC) is inherited as an autosomal dominant disease, characterized by skin lesion and tubers in vital organs, especially brain in three categories including subependymal nodules, cortical tubers and subependymal giant cell astrocytoma. Subependymal giant cell astrocyto...

Descripción completa

Detalles Bibliográficos
Autores principales: Sadeghipour, Alireza, Abdi, Navid, Babaheidarian, Pegah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835379/
https://www.ncbi.nlm.nih.gov/pubmed/29531556
_version_ 1783303806953455616
author Sadeghipour, Alireza
Abdi, Navid
Babaheidarian, Pegah
author_facet Sadeghipour, Alireza
Abdi, Navid
Babaheidarian, Pegah
author_sort Sadeghipour, Alireza
collection PubMed
description BACKGROUND: Tuberous sclerosis (TSC) is inherited as an autosomal dominant disease, characterized by skin lesion and tubers in vital organs, especially brain in three categories including subependymal nodules, cortical tubers and subependymal giant cell astrocytoma. Subependymal giant cell astrocytoma (SEGA) is an indolent neoplasm which usually arises at the cauda thalamic groove near foramen monro, although it occurs usually in the clinical settings of TSC, a few number of SEGA has been reported without such history. Its morphology with special cytoarchitecture could be mistaken with other glial brain tumors with similar morphology. Therefore, investigating new markers for differentiating SEGA from other mimickers seems logical rather than other glioneural immunohistochemical markers introduced before. CASE STUDIES: We investigated CD99 expression in SEGA as an adjunctive marker for diagnostic purposes. Five reported cases of SEGA were studied and all of them showed CD99 expression besides usual glioneural markers. CONCLUSION: CD99 may be a useful adjunctive marker in differentiating SEGA from other mimickers
format Online
Article
Text
id pubmed-5835379
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Iranian Society of Pathology
record_format MEDLINE/PubMed
spelling pubmed-58353792018-03-12 CD99: A potential Diagnostic Marker for Differentiating Sub-ependymal Giant Cell Astrocytoma From Other Mimickers: A Report of Five Cases Sadeghipour, Alireza Abdi, Navid Babaheidarian, Pegah Iran J Pathol Case Report BACKGROUND: Tuberous sclerosis (TSC) is inherited as an autosomal dominant disease, characterized by skin lesion and tubers in vital organs, especially brain in three categories including subependymal nodules, cortical tubers and subependymal giant cell astrocytoma. Subependymal giant cell astrocytoma (SEGA) is an indolent neoplasm which usually arises at the cauda thalamic groove near foramen monro, although it occurs usually in the clinical settings of TSC, a few number of SEGA has been reported without such history. Its morphology with special cytoarchitecture could be mistaken with other glial brain tumors with similar morphology. Therefore, investigating new markers for differentiating SEGA from other mimickers seems logical rather than other glioneural immunohistochemical markers introduced before. CASE STUDIES: We investigated CD99 expression in SEGA as an adjunctive marker for diagnostic purposes. Five reported cases of SEGA were studied and all of them showed CD99 expression besides usual glioneural markers. CONCLUSION: CD99 may be a useful adjunctive marker in differentiating SEGA from other mimickers Iranian Society of Pathology 2017 2017-07-01 /pmc/articles/PMC5835379/ /pubmed/29531556 Text en © 2017, IRANIAN JOURNAL OF PATHOLOGY. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sadeghipour, Alireza
Abdi, Navid
Babaheidarian, Pegah
CD99: A potential Diagnostic Marker for Differentiating Sub-ependymal Giant Cell Astrocytoma From Other Mimickers: A Report of Five Cases
title CD99: A potential Diagnostic Marker for Differentiating Sub-ependymal Giant Cell Astrocytoma From Other Mimickers: A Report of Five Cases
title_full CD99: A potential Diagnostic Marker for Differentiating Sub-ependymal Giant Cell Astrocytoma From Other Mimickers: A Report of Five Cases
title_fullStr CD99: A potential Diagnostic Marker for Differentiating Sub-ependymal Giant Cell Astrocytoma From Other Mimickers: A Report of Five Cases
title_full_unstemmed CD99: A potential Diagnostic Marker for Differentiating Sub-ependymal Giant Cell Astrocytoma From Other Mimickers: A Report of Five Cases
title_short CD99: A potential Diagnostic Marker for Differentiating Sub-ependymal Giant Cell Astrocytoma From Other Mimickers: A Report of Five Cases
title_sort cd99: a potential diagnostic marker for differentiating sub-ependymal giant cell astrocytoma from other mimickers: a report of five cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835379/
https://www.ncbi.nlm.nih.gov/pubmed/29531556
work_keys_str_mv AT sadeghipouralireza cd99apotentialdiagnosticmarkerfordifferentiatingsubependymalgiantcellastrocytomafromothermimickersareportoffivecases
AT abdinavid cd99apotentialdiagnosticmarkerfordifferentiatingsubependymalgiantcellastrocytomafromothermimickersareportoffivecases
AT babaheidarianpegah cd99apotentialdiagnosticmarkerfordifferentiatingsubependymalgiantcellastrocytomafromothermimickersareportoffivecases