Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis

Gut microbiota dysbiosis reduces expression of GLP‐1 receptor (GLP‐1R) and neuronal nitric oxide synthase (nNOS) in the enteric nervous system and hampers GLP‐1‐induced nitric oxide (NO) production through a pattern recognition receptor (PRR)‐dependent mechanism, hence preventing activation of the g...

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Detalles Bibliográficos
Autores principales: Yamane, Shunsuke, Inagaki, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835457/
https://www.ncbi.nlm.nih.gov/pubmed/29034596
http://dx.doi.org/10.1111/jdi.12762
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author Yamane, Shunsuke
Inagaki, Nobuya
author_facet Yamane, Shunsuke
Inagaki, Nobuya
author_sort Yamane, Shunsuke
collection PubMed
description Gut microbiota dysbiosis reduces expression of GLP‐1 receptor (GLP‐1R) and neuronal nitric oxide synthase (nNOS) in the enteric nervous system and hampers GLP‐1‐induced nitric oxide (NO) production through a pattern recognition receptor (PRR)‐dependent mechanism, hence preventing activation of the gut–brain–periphery axis for control of insulin secretion and gastric emptying. [Image: see text]
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spelling pubmed-58354572018-03-07 Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis Yamane, Shunsuke Inagaki, Nobuya J Diabetes Investig Commentary Gut microbiota dysbiosis reduces expression of GLP‐1 receptor (GLP‐1R) and neuronal nitric oxide synthase (nNOS) in the enteric nervous system and hampers GLP‐1‐induced nitric oxide (NO) production through a pattern recognition receptor (PRR)‐dependent mechanism, hence preventing activation of the gut–brain–periphery axis for control of insulin secretion and gastric emptying. [Image: see text] John Wiley and Sons Inc. 2017-12-01 2018-03 /pmc/articles/PMC5835457/ /pubmed/29034596 http://dx.doi.org/10.1111/jdi.12762 Text en © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentary
Yamane, Shunsuke
Inagaki, Nobuya
Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis
title Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis
title_full Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis
title_fullStr Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis
title_full_unstemmed Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis
title_short Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis
title_sort regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835457/
https://www.ncbi.nlm.nih.gov/pubmed/29034596
http://dx.doi.org/10.1111/jdi.12762
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