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Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans

In mental time travel (MTT) one is “traveling” back-and-forth in time, remembering, and imagining events. Despite intensive research regarding memory processes in the hippocampus, it was only recently shown that the hippocampus plays an essential role in encoding the temporal order of events remembe...

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Autores principales: Schurr, Roey, Nitzan, Mor, Eliahou, Ruth, Spinelli, Laurent, Seeck, Margitta, Blanke, Olaf, Arzy, Shahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835533/
https://www.ncbi.nlm.nih.gov/pubmed/29541024
http://dx.doi.org/10.3389/fncom.2018.00011
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author Schurr, Roey
Nitzan, Mor
Eliahou, Ruth
Spinelli, Laurent
Seeck, Margitta
Blanke, Olaf
Arzy, Shahar
author_facet Schurr, Roey
Nitzan, Mor
Eliahou, Ruth
Spinelli, Laurent
Seeck, Margitta
Blanke, Olaf
Arzy, Shahar
author_sort Schurr, Roey
collection PubMed
description In mental time travel (MTT) one is “traveling” back-and-forth in time, remembering, and imagining events. Despite intensive research regarding memory processes in the hippocampus, it was only recently shown that the hippocampus plays an essential role in encoding the temporal order of events remembered, and therefore plays an important role in MTT. Does it also encode the temporal relations of these events to the remembering self? We asked patients undergoing pre-surgical evaluation with depth electrodes penetrating the temporal lobes bilaterally toward the hippocampus to project themselves in time to a past, future, or present time-point, and then make judgments regarding various events. Classification analysis of intracranial evoked potentials revealed clear temporal dissociation in the left hemisphere between lateral-temporal electrodes, activated at ~100–300 ms, and hippocampal electrodes, activated at ~400–600 ms. This dissociation may suggest a division of labor in the temporal lobe during self-projection in time, hinting toward the different roles of the lateral-temporal cortex and the hippocampus in MTT and the temporal organization of the related events with respect to the experiencing self.
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spelling pubmed-58355332018-03-14 Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans Schurr, Roey Nitzan, Mor Eliahou, Ruth Spinelli, Laurent Seeck, Margitta Blanke, Olaf Arzy, Shahar Front Comput Neurosci Neuroscience In mental time travel (MTT) one is “traveling” back-and-forth in time, remembering, and imagining events. Despite intensive research regarding memory processes in the hippocampus, it was only recently shown that the hippocampus plays an essential role in encoding the temporal order of events remembered, and therefore plays an important role in MTT. Does it also encode the temporal relations of these events to the remembering self? We asked patients undergoing pre-surgical evaluation with depth electrodes penetrating the temporal lobes bilaterally toward the hippocampus to project themselves in time to a past, future, or present time-point, and then make judgments regarding various events. Classification analysis of intracranial evoked potentials revealed clear temporal dissociation in the left hemisphere between lateral-temporal electrodes, activated at ~100–300 ms, and hippocampal electrodes, activated at ~400–600 ms. This dissociation may suggest a division of labor in the temporal lobe during self-projection in time, hinting toward the different roles of the lateral-temporal cortex and the hippocampus in MTT and the temporal organization of the related events with respect to the experiencing self. Frontiers Media S.A. 2018-02-28 /pmc/articles/PMC5835533/ /pubmed/29541024 http://dx.doi.org/10.3389/fncom.2018.00011 Text en Copyright © 2018 Schurr, Nitzan, Eliahou, Spinelli, Seeck, Blanke and Arzy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Schurr, Roey
Nitzan, Mor
Eliahou, Ruth
Spinelli, Laurent
Seeck, Margitta
Blanke, Olaf
Arzy, Shahar
Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans
title Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans
title_full Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans
title_fullStr Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans
title_full_unstemmed Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans
title_short Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans
title_sort temporal dissociation of neocortical and hippocampal contributions to mental time travel using intracranial recordings in humans
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835533/
https://www.ncbi.nlm.nih.gov/pubmed/29541024
http://dx.doi.org/10.3389/fncom.2018.00011
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