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Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation

AKT signaling is modulated by a complex network of regulatory proteins and is commonly deregulated in cancer. Here, we present a dual mechanism of AKT regulation by the ERBB receptor feedback inhibitor 1 (ERRFI1). We show that in cells expressing high levels of EGFR, ERRF1 inhibits growth and enhanc...

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Detalles Bibliográficos
Autores principales:	Cairns, Junmei, Fridley, Brooke L, Jenkins, Gregory D, Zhuang, Yongxian, Yu, Jia, Wang, Liewei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835844/ https://www.ncbi.nlm.nih.gov/pubmed/29335246 http://dx.doi.org/10.15252/embr.201744767

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