PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses

Class-switch recombination (CSR) and somatic hypermutation (SHM) occur during the differentiation of germinal center B cells (GCBs). Activation-induced cytidine deaminase (AID) is responsible for both CSR and SHM in GCBs. Here, we show that ablation of PTEN through the Cγ1-Cre mediated recombination...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Liu, Sichen, Hou, Baidong, Yang, Meixiang, Dong, Zhongjun, Qi, Hai, Liu, Wanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835858/
https://www.ncbi.nlm.nih.gov/pubmed/29541074
http://dx.doi.org/10.3389/fimmu.2018.00371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835858/
https://www.ncbi.nlm.nih.gov/pubmed/29541074
http://dx.doi.org/10.3389/fimmu.2018.00371

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