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Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study
BACKGROUND: There are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood. OBJECTIVE: Thi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835900/ https://www.ncbi.nlm.nih.gov/pubmed/29541037 http://dx.doi.org/10.3389/fpsyt.2018.00052 |
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author | Yoshimura, Reiji Kishi, Taro Atake, Kiyokazu Katsuki, Asuka Iwata, Nakao |
author_facet | Yoshimura, Reiji Kishi, Taro Atake, Kiyokazu Katsuki, Asuka Iwata, Nakao |
author_sort | Yoshimura, Reiji |
collection | PubMed |
description | BACKGROUND: There are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood. OBJECTIVE: This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD). MATERIALS AND METHODS: A total of 148 patients (male/female 65/83, age 49.5 ± 12.1 years old) who satisfied criteria for MD based on the Diagnostic and Statistical Manual of Mental Disorders IV were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA. RESULTS: No interactions were observed between plasma HVA levels (mean ± SD = 4.5 ± 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels (mean ± SD = 9.8 ± 2.9 ng/mL). No correlations were not also observed between plasma MHPG levels (mean ± SD = 5.9 ± 2.1 ng/mL) and age, sex, the HAMD17 scores (mean ± SD = 22.2 ± 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores. CONCLUSION: The results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients. |
format | Online Article Text |
id | pubmed-5835900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58359002018-03-14 Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study Yoshimura, Reiji Kishi, Taro Atake, Kiyokazu Katsuki, Asuka Iwata, Nakao Front Psychiatry Psychiatry BACKGROUND: There are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood. OBJECTIVE: This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD). MATERIALS AND METHODS: A total of 148 patients (male/female 65/83, age 49.5 ± 12.1 years old) who satisfied criteria for MD based on the Diagnostic and Statistical Manual of Mental Disorders IV were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA. RESULTS: No interactions were observed between plasma HVA levels (mean ± SD = 4.5 ± 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels (mean ± SD = 9.8 ± 2.9 ng/mL). No correlations were not also observed between plasma MHPG levels (mean ± SD = 5.9 ± 2.1 ng/mL) and age, sex, the HAMD17 scores (mean ± SD = 22.2 ± 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores. CONCLUSION: The results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients. Frontiers Media S.A. 2018-02-28 /pmc/articles/PMC5835900/ /pubmed/29541037 http://dx.doi.org/10.3389/fpsyt.2018.00052 Text en Copyright © 2018 Yoshimura, Kishi, Atake, Katsuki and Iwata. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Yoshimura, Reiji Kishi, Taro Atake, Kiyokazu Katsuki, Asuka Iwata, Nakao Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study |
title | Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study |
title_full | Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study |
title_fullStr | Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study |
title_full_unstemmed | Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study |
title_short | Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study |
title_sort | serum brain-derived neurotrophic factor, and plasma catecholamine metabolites in people with major depression: preliminary cross-sectional study |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835900/ https://www.ncbi.nlm.nih.gov/pubmed/29541037 http://dx.doi.org/10.3389/fpsyt.2018.00052 |
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